Optimizacija izolacije virusov z lipidno ovojnico pri proizvodnji cepiv

diplomsko delo

Diana Žnidaršič (Author), Aleš Podgornik (Mentor)

Abstract

Proizvodnja cepiv proti virusnim okužbam postaja vedno bolj pomembna, saj z njo lahko preprečimo množično širjenje okužb. Cepiva so lahko proizvedena iz virusom podobnih delcev, oslabljenih živih virusov, mrtvih virusnih delcev, očiščenih delov virusa, vektorskih cepiv in cepiv na osnovi nukleinskih kislin. Viruse, kot glavna sestavina cepiva, lahko delimo na vijačne, ikozaedrične, kompleksne in viruse z ovojnico. Virusi z ovojnico predstavljajo velik izziv za njihovo karakterizacijo in izolacijo, zaradi nespecifičnih interakcij, ki jih povzroča lipidni dvosloj, Z ustrezno sklopitvijo poznanih separacijskih tehnik želimo najprej doseči čim manjši neželeni odziv pri posamezniku in hkrati čim bolj čist, ekonomičen ter konkurenčen produkt na trgu cepiv.

Keywords

virusi z lipidno ovojnico;cepiva;proizvodnja cepiv;izolacija virusov;separacija;separacijske tehnike;diplomska dela;

Data

Language:	Slovenian
Year of publishing:	2021
Typology:	2.11 - Undergraduate Thesis
Organization:	UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher:	[D. Žnidaršič]
UDC:	602.44(043.2)
COBISS:	90865667
Views:	122
Downloads:	16
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Optimisation of the lipid-enveloped viruses isolation in vaccine production
Secondary abstract:	The production of vaccines against viral infections is becoming increasingly important as it can prevent the mass spread of infections. Vaccines are made from virus-like particles, live-attenuated viruses, dead virus particles, purified virus parts, viral vector vaccines and nucleic acid vaccines. Viruses, as a main part of vaccines, are divided into helical, icosahedral, complex and enveloped viruses. Enveloped viruses present a major challenge for their characterisation and isolation, due to non-specific interactions caused by the lipid bilayer. With the correct order of known separation techniques we want to achieve the cleanest, most cost-effective and competitive product on the vaccine market and to reduce side effects with the patient.
Secondary keywords:	enveloped viruses;vaccines;isolation;separation techniques;
Type (COBISS):	Bachelor thesis/paper
Study programme:	1000372
Thesis comment:	Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, UNI Kemijsko inženirstvo
Pages:	20 str.
ID:	14759912