Aljaž Velikonja (Author), Poornima Budime Santhosh (Author), Ekaterina Gongadze (Author), Mukta Vishwanath Kulkarni (Author), Kristina Eleršič (Author), Šárka Perutková (Author), Veronika Kralj-Iglič (Author), Nataša Poklar Ulrih (Author), Aleš Iglič (Author)

Abstract

In this work, a theoretical model describing the interaction between a positively or negatively charged nanoparticle and neutral zwitterionic lipid bilayers is presented. It is shown that in the close vicinity of the positively charged nanoparticle, the zwitterionic lipid headgroups are less extended in the direction perpendicular to the membrane surface, while in the vicinity of the negatively charged nanoparticle, the headgroups are more extended. This result coincides with the calculated increase in the osmotic pressure between the zwitterionic lipid surface and positively charged nanoparticle and the decrease of osmotic pressure between the zwitterionic lipid surface and the negatively charged nanoparticle. Our theoretical predictions agree well with the experimentally determined fluidity of a lipid bilayer membrane in contact with positively or negatively charged nanoparticles. The prospective significance of the present work is mainly to contribute to better understanding of the interactions of charged nanoparticles with a zwitterionic lipid bilayer, which may be important in the efficient design of the lipid/nanoparticle nanostructures (like liposomes with encapsulated nanoparticles), which have diverse biomedical applications, including targeted therapy (drug delivery) and imaging of cancer cells.

Keywords

biološke membrane;biofizika membrane;lipidi;nanodelci;elektrostatske interakcije;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL FE - Faculty of Electrical Engineering
UDC: 577.352:576.314
COBISS: 4257144 Link will open in a new window
ISSN: 1422-0067
Views: 1105
Downloads: 324
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Other data

Secondary language: Slovenian
Secondary keywords: biološke membrane;biofizika membrane;lipidi;nanodelci;elektrostatske interakcije;
Type (COBISS): Article
Pages: str. 15312-15329
Volume: ǂVol. ǂ14
Issue: ǂno. ǂ8
Chronology: 2013
DOI: 10.3390/ijms140815312
ID: 1478040