Tatjana Vilibić-Čavlek (Author), Tena Oreški (Author), Miša Korva (Author), Branko Kolarič (Author), Vladimir Stevanovic (Author), Snježana Židovec-Lepej (Author), Irena Tabain (Author), Pavle Jelicic (Author), Bozana Miklausic-Pavic (Author), Vladimir Savić (Author), Ljubo Barbić (Author), Tatjana Avšič-Županc (Author)

Abstract

Lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen associated with aseptic meningitis, severe systemic infections in immunocompromised persons, and congenital anomalies. Data on the prevalence of LCMV infections are scarce. We analyzed the seroprevalence of LCMV in continental Croatian regions. A total of 338 serum samples of professionally exposed (forestry workers, hunters, agriculture workers in contact with rodents) and non-exposed populations (general population, pregnant women) were tested for the presence of LCMV antibodies using indirect immunofluorescence assay. No participants reported recent febrile disease. LCMV IgG antibodies were detected in 23/6.8% of participants: 9.8% exposed persons and 5.1% non-exposed persons (6.1% in the general population and 3.9% in pregnant women). No participants were LCMV IgM positive. Although higher seropositivity was found in males compared to females (8.9% vs. 4.7%), inhabitants of suburban/rural areas compared to inhabitants of urban areas (9.2% vs. 4.6%), and persons who used well as a source of water compared to those who used tap (11.4% vs. 5.6%), these differences did not reach statistical significance. Results of logistic regression showed that the presence of rodents in the house/yard and cleaning rodent nests were associated with an elevated risk for LCMV infection (OR = 2.962, 95% CI = 1.019–8.607).

Keywords

lymphocytic choriomeningitis virus;seroprevalence;general population;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL MF - Faculty of Medicine
UDC: 616.9
COBISS: 67793923 Link will open in a new window
ISSN: 2414-6366
Views: 98
Downloads: 39
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Other data

Secondary language: Slovenian
Secondary keywords: virus limfocitnega horiomeningitisa;seroprevalenca;splošno prebivalstvo;
Type (COBISS): Article
Pages: str. 1-10
Volume: ǂVol. ǂ6
Issue: ǂiss. ǂ2
Chronology: 2021
DOI: 10.3390/tropicalmed6020067
ID: 14785308