Darja Keše (Author), Aljoša Obreza (Author), Tereza Rojko (Author), Tjaša Cerar (Author)

Abstract

Legionella pneumophila is the causative agent of severe Legionnaires' disease (LD). Although an increasing number of LD cases have been observed, published data from Slovenia are very limited and data on molecular epidemiology are even scarcer. The present retrospective study (2006-2020) reports the results of the microbiological diagnosis of LD, as well as the epidemiology and characterization of the Legionella clinical isolates. We tested urine samples from 15,540 patients with pneumonia symptoms for L. pneumophila infection by urine antigen test, of which 717 (4.6%) tested positive. Isolation of L. pneumophila was successfully performed from 88 clinical specimens, with 82 (93.2%) being identified as L. pneumophila sg 1 and six (6.8%) as L. pneumophila sg 2-14. Sequence-based typing (SBT) identified 33 different sequence types (STs), the most frequent being ST1 and ST23. Sequence type 1 mainly comprised isolates belonging to the Philadelphia subgroup, and ST23 mostly to Allentown/France. The standard SBT scheme, as well as Dresden phenotyping for L. pneumophila, presented a high diversity among isolates.

Keywords

Legionnaires' disease;diagnosis;epidemiology;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL MF - Faculty of Medicine
UDC: 616.9
COBISS: 69395715 Link will open in a new window
ISSN: 2075-4418
Views: 91
Downloads: 35
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Other data

Secondary language: Slovenian
Secondary keywords: Legionarska bolezen;diagnoza;epidemiologija;
Type (COBISS): Article
Pages: str. 1-11
Volume: ǂVol. ǂ11
Issue: ǂiss. ǂ7
Chronology: May 2021
DOI: 10.3390/diagnostics11071201
ID: 14889996