Matrix metalloproteinases as biomarkers and treatment targets in mesothelioma

Danijela Štrbac (Author), Vita Dolžan (Author)

Abstract

Metalloproteinases (MMPs) have an important role in tissue remodeling and have been shown to have an effect on tumor progression, invasion, metastasis formation, and apoptosis in several tumors, including mesothelioma. Mesothelioma is a rare tumor arising from pleura and peritoneum and is frequently associated with asbestos exposure. We have performed a systematic search of PubMed.gov and ClinicalTrials.gov databases to retrieve and review three groups of studies: studies of MMPs expression in tumor tissue or body fluids in patients with mesothelioma, studies of MMPs genetic variability, and studies of MMPs as potential novel drug targets in mesothelioma. Several studies of MMPs in mesothelioma tissues reported a link between higher expression levels of commonly studied MMPs and clinical parameters, such as overall survival. Fewer studies have investigated genetic variability of MMP genes. Nevertheless, these studies suggested that certain genetic variants in MMP genes can have either protective or tumor-promoting effects on mesothelioma patients. MMPs have been also reported as novel drug targets, but so far no clinical trials of MMP inhibitors are registered in mesothelioma. In conclusion, MMPs play an important role in mesothelioma, but further studies are needed to elucidate the potentials of MMPs as biomarkers and drug targets in mesothelioma.

Keywords

mezoteliom;metaloproteinaza;genetska variabilnost;mesothelioma;metalloproteinases;genetic variability;

Data

Language:	English
Year of publishing:	2021
Typology:	1.02 - Review Article
Organization:	UL MF - Faculty of Medicine
UDC:	616-006
COBISS:	74658819
ISSN:	2218-273X
Views:	146
Downloads:	44
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	mezoteliom;metaloproteinaza;genetska variabilnost;
Type (COBISS):	Article
Pages:	str. 1-10
Volume:	ǂVol. ǂ11
Issue:	ǂno. ǂ9
Chronology:	2021
DOI:	10.3390/biom11091272
ID:	14976282