Marija Gjorgoska (Author), Tea Lanišnik-Rižner (Author)

Abstract

Ovarian cancer is a heterogeneous disease affecting the aging ovary, in concert with a complex network of cells and signals, together representing the ovarian tumor microenvironment. As in the "Schrödinger's cat" thought experiment, the context-dependent constituents of the-by the time of diagnosis-well-established tumor microenvironment may display a tumor-protective and -destructive role. Systemic and locally synthesized estrogens contribute to the formation of a pro-tumoral microenvironment that enables the sustained tumor growth, invasion and metastasis. Here we focus on the estrogen biosynthetic and metabolic pathways in ovarian cancer and elaborate their actions on phenotypically plastic, estrogen-responsive, aging immune cells of the tumor microenvironment, altogether highlighting the multicomponent-connectedness and complexity of cancer, and contributing to a broader understanding of the ovarian cancer biology.

Keywords

rak jajčnikov;estrogeni;imunosupresivno mikrookolje;ovarian cancer;estrogens;immunosuppressive microenvironment;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UL MF - Faculty of Medicine
UDC: 616-006
COBISS: 79662851 Link will open in a new window
ISSN: 2072-6694
Views: 78
Downloads: 29
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary language: Slovenian
Secondary keywords: rak jajčnikov;estrogeni;imunosupresivno mikrookolje;
Type (COBISS): Article
Pages: str. 1-18
Volume: ǂVol. ǂ13
Issue: ǂiss. ǂ19
Chronology: 2021
DOI: 10.3390/cancers13195011
ID: 15098312