Oral glucose load and human cutaneous microcirculation

ǂan ǂinsight into flowmotion assessed by wavelet transform

Henrique Silva (Author), Jernej Šorli (Author), Helena Lenasi (Author)

Abstract

Microcirculation in vivo has been assessed using non-invasive technologies such as laser Doppler flowmetry (LDF). In contrast to chronic hyperglycemia, known to induce microvascular dysfunction, the effects of short-term elevations in blood glucose on microcirculation are controversial. We aimed to assess the impact of an oral glucose load (OGL) on the cutaneous microcirculation of healthy subjects, quantified by LDF and coupled with wavelet transform (WT) as an interpretation tool. On two separate occasions, sixteen subjects drank either a glucose solution (75 g in 250 mL water) or water (equal volume). LDF signals were obtained in two anatomical sites (forearm and finger pulp) before and after each load (pre-load and post-load, respectively), in resting conditions and during post-occlusive reactive hyperemia (PORH). The WT allowed decomposition of the LDF signals into their spectral components (cardiac, respiratory, myogenic, sympathetic, endothelial NO-dependent). The OGL blunted the PORH response in the forearm, which was not observed with the water load. Significant differences were found for the cardiac and sympathetic components in the glucose and water groups between the pre-load and post-load periods. These results suggest that an OGL induces a short-term subtle microvascular impairment, probably involving a modulation of the sympathetic nervous system.

Keywords

diabetes mellitus;microcirculation;laser Doppler flowmetry;

Data

Language:	English
Year of publishing:	2021
Typology:	1.01 - Original Scientific Article
Organization:	UL MF - Faculty of Medicine
UDC:	612
COBISS:	83675651
ISSN:	2079-7737
Views:	68
Downloads:	35
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	sladkorna bolezen;mikrocirkulacija;laserska Dopplerjeva flowmetrija;
Type (COBISS):	Article
Pages:	str. 1-17
Volume:	ǂVol. ǂ10
Issue:	ǂiss. ǂ10
Chronology:	2021
DOI:	10.3390/biology10100953
ID:	15129370