Highly sensitive amperometric detection of hydrogen peroxide in saliva based on N-doped graphene nanoribbons and MnO [sub] 2 modified carbon paste electrodes

Ema Gričar (Author), Kurt Kalcher (Author), Boštjan Genorio (Author), Mitja Kolar (Author)

Abstract

Four different graphene-based nanomaterials (htGO, N-htGO, htGONR, and N-htGONR) were synthesized, characterized, and used as a modifier of carbon paste electrode (CPE) in order to produce a reliable, precise, and highly sensitive non-enzymatic amperometric hydrogen peroxide sensor for complex matrices. CPE, with their robustness, reliability, and ease of modification, present a convenient starting point for the development of new sensors. Modification of CPE was optimized by systematically changing the type and concentration of materials in the modifier and studying the prepared electrode surface by cyclic voltammetry. N-htGONR in combination with manganese dioxide (1:1 ratio) proved to be the most appropriate material for detection of hydrogen peroxide in pharmaceutical and saliva matrices. The developed sensor exhibited a wide linear range (1.0–300 µM) and an excellent limit of detection (0.08 µM) and reproducibility, as well as high sensitivity and stability. The sensor was successfully applied to real sample analysis, where the recovery values for a commercially obtained pharmaceutical product were between 94.3% and 98.0%. Saliva samples of a user of the pharmaceutical product were also successfully analyzed.

Keywords

elektrokemijski senzorji;vodikov peroksid;grafen;grafenski nanotrakovi;amperometrija;electrochemical sensors;hydrogen peroxide;graphene;graphene nanoribbons;amperometry;

Data

Language:	English
Year of publishing:	2021
Typology:	1.01 - Original Scientific Article
Organization:	UL FKKT - Faculty of Chemistry and Chemical Technology
UDC:	543.553
COBISS:	89121539
ISSN:	1424-8220
Views:	88
Downloads:	50
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	elektrokemijski senzorji;vodikov peroksid;grafen;grafenski nanotrakovi;amperometrija;
Type (COBISS):	Article
Pages:	str. 1-14
Volume:	ǂVol. ǂ21
Issue:	ǂiss. ǂ24
Chronology:	Dec. 2021
DOI:	10.3390/s21248301
ID:	15288115