Treatment of benign prostatic hyperplasia by natural drugs

Eszter Csikós (Author), Adrienn Horváth (Author), Kamilla Ács (Author), Nóra Papp (Author), Viktória Lilla Balázs (Author), Marija Sollner Dolenc (Author), Maša Kenda (Author), Nina Kočevar Glavač (Author), Milan Nagy (Author), Michele Protti (Author)

Abstract

Benign prostatic hyperplasia (BPH) is one of the most common urinary diseases affecting men, generally after the age of 50. The prevalence of this multifactorial disease increases with age. With aging, the plasma level of testosterone decreases, as well as the testosterone/estrogen ratio, resulting in increased estrogen activity, which may facilitate the hyperplasia of the prostate cells. Another theory focuses on dihydrotestosterone (DHT) and the activity of the enzyme 5[alpha]-reductase, which converts testosterone to DHT. In older men, the activity of this enzyme increases, leading to a decreased testosterone/DHT ratio. DHT may promote prostate cell growth, resulting in hyperplasia. Some medicinal plants and their compounds act by modulating this enzyme, and have the above-mentioned targets. This review focuses on herbal drugs that are most widely used in the treatment of BPH, including pumpkin seed, willow herb, tomato, maritime pine bark, Pygeum africanum bark, rye pollen, saw palmetto fruit, and nettle root, highlighting the latest results of preclinical and clinical studies, as well as safety issues. In addition, the pharmaceutical care and other therapeutic options of BPH, including pharmacotherapy and surgical options, are discussed, summarizing and comparing the advantages and disadvantages of each therapy.

Keywords

predklinične študije;klinična učinkovitost;varnostne težave;benign prostatic hyperplasia;medicinal plants;phytotherapy;saw palmetto;preclinical studies;clinical efficacy;safety issues;

Data

Language:	English
Year of publishing:	2021
Typology:	1.02 - Review Article
Organization:	UL FFA - Faculty of Pharmacy
UDC:	616.65-007.61
COBISS:	86644739
ISSN:	1420-3049
Views:	187
Downloads:	78
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	Benigna prostatična hiperplazija;Zdravilne rastline;Fitoterapija;
Type (COBISS):	Article
Source comment:	V članku na koncu seznama avtorjev navedeno: "and on behalf of the OEMONOM" (datum opombe 17. 5. 2022).
Pages:	str. 1-32
Volume:	ǂVol. ǂ26
Issue:	ǂiss. ǂ23
Chronology:	2021
DOI:	10.3390/molecules26237141
ID:	15337764