Phi 6 bacteriophage inactivation by metal salts, metal powders, and metal surfaces

Katja Molan (Author), Ramin Rahmani (Author), Daniel Krklec (Author), Miha Brojan (Author), David Stopar (Author)

Abstract

The interaction of phages with abiotic environmental surfaces is usually an understudied field of phage ecology. In this study, we investigated the virucidal potential of different metal salts, metal and ceramic powders doped with Ag and Cu ions, and newly fabricated ceramic and metal surfaces against Phi6 bacteriophage. The new materials were fabricated by spark plasma sintering (SPS) and/or selective laser melting (SLM) techniques and had different surface free energies and infiltration features. We show that inactivation of Phi6 in solutions with Ag and Cu ions can be as effective as inactivation by pH, temperature, or UV. Adding powder to Ag and Cu ion solutions decreased their virucidal effect. The newly fabricated ceramic and metal surfaces showed very good virucidal activity. In particular, 45%TiO$_2$ + 5%Ag + 45%ZrO$_2$ + 5%Cu, in addition to virus adhesion, showed virucidal and infiltration properties. The results indicate that more than 99.99% of viruses deposited on the new ceramic surface were inactivated or irreversibly attached to it.

Keywords

bakteriofagi;Phi 6;kovinski ioni;soli;prah;kompoziti;bacteriophage Phi6;metal salts;ceramic–metal powders;metals;composite materials;

Data

Language:	English
Year of publishing:	2022
Typology:	1.01 - Original Scientific Article
Organization:	UL BF - Biotechnical Faculty
UDC:	578.347:615.281.8:546.3
COBISS:	94779907
ISSN:	1999-4915
Views:	72
Downloads:	27
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	bakteriofagi;Phi 6;kovinski ioni;soli;prah;kompoziti;
Type (COBISS):	Article
Pages:	str. 1-12, art. 204
Volume:	ǂVol. ǂ14
Issue:	ǂiss. ǂ2
Chronology:	2022
DOI:	10.3390/v14020204
ID:	15504082