Cervical intraepithelial neoplasia grade 3 in a HPV-vaccinated patient

ǂa ǂcase report

Mateja Sladič (Author), Pepita Taneska (Author), Branko Cvjetičanin (Author), Mojca Velikonja (Author), Vladimir Smrkolj (Author), Špela Smrkolj (Author)

Abstract

Persistent infection with human papillomavirus (HPV) causes almost all cervical precancerous lesions and cancers. Bivalent, quadrivalent, and nonavalent HPV vaccines effectively prevent high-grade cervical intraepithelial neoplasia (CIN3). The effectiveness of HPV vaccination against CIN3 is 97–100% in HPV-naïve populations and 44–61% in the overall population. Although HPV vaccination has substantially reduced the incidence of cervical cancers, several cases of precancerous cervical lesions in HPV-vaccinated patients have been reported. We report the clinical case of a 19-year-old woman whose first Pap smear was diagnosed as a high-grade squamous intraepithelial lesion (HSIL) after quadrivalent HPV vaccination. Colposcopy and cervical biopsy were performed, revealing HSIL/CIN3. Our multidisciplinary team decided to take a conservative approach with follow-up visits with cervical biopsies of this young patient. After six months, spontaneous regression of high-grade cervical dysplasia was observed. Although HPV immunization has shown to be extremely effective in preventing a high proportion of cervical precancerous lesions and cervical cancers, HPV vaccines do not protect against all oncogenic high-risk HPV genotypes. Consequently, healthcare providers must encourage HPV-vaccinated women to still regularly attend national cervical screening programs.

Keywords

cepljenje proti papilomavirusu;maternični vrat;rak materničnega vratu;intraepitelna neoplazija;ginekologija;

Data

Language:	English
Year of publishing:	2022
Typology:	1.03 - Short Scientific Article
Organization:	UL MF - Faculty of Medicine
UDC:	618.1
COBISS:	98924803
ISSN:	1648-9144
Views:	89
Downloads:	23
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	cepljenje proti papilomavirusu;maternični vrat;rak materničnega vratu;intraepitelna neoplazija;ginekologija;
Type (COBISS):	Article
Pages:	str. 1-7
Volume:	ǂVol. ǂ58
Issue:	ǂiss. ǂ3
Chronology:	2022
DOI:	10.3390/medicina58030339
ID:	15574441