Association of myocardial infarction with CDKN2B antisense RNA 1 (CDKN2B-AS1) rs1333049 polymorphism in Slovenian subjects with type 2 diabetes mellitus

Miha Tibaut (Author), Franjo Naji (Author), Danijel Petrovič (Author)

Abstract

Background: We examined the role of rs1333049 polymorphism of the CDKN2B Antisense RNA 1 (CDKN2B-AS1) on the prevalence of myocardial infarction (MI) in Slovenian subjects with type 2 diabetes mellitus (T2DM). Methods: A total of 1071 subjects with T2DM were enrolled in this retrospective cross-sectional case-control study. Of the subjects, 334 had a history of recent MI, and 737 subjects in the control group had no clinical signs of coronary artery disease (CAD). With logistic regression, we performed a genetic analysis of rs1333049 polymorphism in all subjects. Results: The C allele of rs1333049 polymorphism was statistically more frequent in MI subjects (p = 0.05). Subjects with CC genotype had a higher prevalence of MI than the control group in the co-dominant (AOR 1.50, CI 1.02-2.21, p = 0.04) and recessive (AOR 1.38, CI 1.09-1.89, p = 0.04) genetic model. Conclusions: According to our study, the C allele and CC genotype of rs1333049 polymorphism of CDKN2B-AS1 are possible markers of MI in T2DM subjects in the Slovenian population.

Keywords

sladkorna bolezen tip 2;miokardni infarkt;bolezen koronarnih arterij;type 2 diabetes mellitus;myocardial infarction;coronary artery disease;

Data

Language:	English
Year of publishing:	2022
Typology:	1.01 - Original Scientific Article
Organization:	UL MF - Faculty of Medicine
UDC:	616.1
COBISS:	102534915
ISSN:	2073-4425
Views:	63
Downloads:	23
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	sladkorna bolezen tip 2;miokardni infarkt;bolezen koronarnih arterij;
Type (COBISS):	Article
Pages:	str. 1-8
Volume:	ǂVol. ǂ13
Issue:	ǂiss. ǂ3
Chronology:	2022
DOI:	10.3390/genes13030526
ID:	15702043