ǂa ǂretrospective analysis from an early access program
Oliver Illini (Author), Hannah Fabikan (Author), Aurélie Swalduz (Author), Anders Vikström (Author), Dagmar Krenbek (Author), Michael Schumacher (Author), Maximilian J Hochmair (Author), Elizabeth Dudnik (Author), Michael Studnicka (Author), Ronny Öhman (Author), Robert Wurm (Author), Tanja Čufer (Author), Katja Mohorčič (Author)

Abstract

Background: Patients with non-small cell lung cancer (NSCLC) presenting with mesenchymal–epithelial transition (MET) exon 14 skipping mutation have an unfavorable prognosis with standard treatments. Capmatinib is a selective MET inhibitor, which showed promising efficacy in this patient population in early trials. Methods: We performed a retrospective, international, multicenter efficacy and safety analysis in patients with NSCLC treated with capmatinib in an early access program between March 2019 and December 2021. Results: Data from 81 patients with advanced MET exon 14 mutated NSCLC treated with capmatinib in first- or later-line therapy were analyzed. Median age was 77years (range, 48–91), 56% were women, 86% had stage IV disease, and 27% had brain metastases. For all patients, the objective response rate (ORR) to capmatinib was 58% (95% CI, 47–69), whereas it was 68% (95% CI, 50–82) in treatment-naïve and 50% (95% CI, 35–65) in pretreated patients. The median progression-free survival was 9.5months (95% CI, 4.7–14.3), whereas it was 10.6months (95% CI, 5.5–15.7) in first-line and 9.1months (95% CI, 3.1–15.1) in pretreated patients. After a median follow-up of 11.0months, the median overall survival was 18.2 months (95% CI, 13.2–23.1). In patients with measurable brain metastases (n=11), the intracranial ORR was 46% (95% CI, 17–77). Capmatinib showed a manageable safety profile. Grade⩾3 treatment-related adverse events included peripheral edema (13%), elevated creatinine (4%), and elevated liver enzymes (3%). Conclusion: In patients with MET exon 14 skipping mutation, capmatinib showed durable systemic and intracranial efficacy and a manageable safety profile. This analysis confirms previously reported phase II data in a real-world setting.

Keywords

podatki iz resničnega življenja;capmatinib;tarčna terapija;real-world data;targeted therapy;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Publisher: Sage Publications
UDC: 616-006
COBISS: 112187139 Link will open in a new window
ISSN: 1758-8359
Views: 76
Downloads: 76
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Other data

Secondary keywords: Carcinoma, non-small cell lung;Drug therapy;Genetics;Molecular targeted therapy;Nedrobnocelični karcinom pljuč;Terapija z zdravili;Genetika;Molekularna tarčna terapija;
Source comment: Nasl. z nasl. zaslona; Soavtorici iz Slovenije: Katja Mohorčič, Tanja Čufer; Opis vira z dne 20. 6. 2022;
Pages: str. 1-22
Issue: ǂVol. ǂ14
Chronology: Jan./Dec. 2022
DOI: 10.1177/17588359221103206
ID: 15730078