master's thesis
Álvaro Pequeno Alonso (Author), Maša Knez Hrnčič (Mentor), Željko Knez (Co-mentor)

Abstract

Arnica Montana je obetaven vir bioaktivnih spojin, predvsem fenolov, ki zaradi svoje antioksidativne aktivnosti izkazujejo koristi za zdravje ljudi. Da bi dosegli stopnjo farmacevtske uporabe, je treba cvetove Arnice Montana predelati v izdelek, ki je primeren za preživetje. V ta namen so bile izvedene različne ekstrakcijske tehnike z različnimi topili: hladna maceracija, ultrazvok, Soxhlet in superkritični CO2; uporabljena topila so bila etanol, metanol in mešanica etanola in vode 95:5 (v:v). Analiza, ki je vključevala ultravijolično/vidno spektrometrijo, je bila opravljena za merjenje antioksidativne aktivnosti in celotne vsebnosti fenolov v ekstraktih. Končno je bil organogel oblikovan z uporabo izvlečka, olja konoplje in voska riževih otrobov ter testiran glede njegove stabilnosti. V okviru tega dela je bil prvič formuliran organogel z visoko stabilnostjo, saj do sedaj v znanstveni literaturi ni bilo podatkov o tovrstni formulaciji. Za določitev njegovih reoloških lastnosti in topnosti v različnih topilih pri različnih temperaturnih pogojih bodo potrebne dodatne študije.

Keywords

cvetovi Arnice Montane;bioaktivne spojine;fenoli;superkritični fluidi;Arnica Montana;organogels;solvent extraction;phenolic compounds;supercritical fluid extraction;

Data

Language: English
Year of publishing:
Typology: 2.09 - Master's Thesis
Organization: UM FKKT - Faculty of Chemistry and Chemical Engineering
Publisher: [A. Pequeno Alonso]
UDC: 66.061.3:633.88(043.2)
COBISS: 116232963 Link will open in a new window
Views: 67
Downloads: 5
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Other data

Secondary language: Slovenian
Secondary title: Optimization of extraction of active compounds from arnica montana and product formulation
Secondary abstract: Arnica Montana is a promising source of bioactive compounds, mainly phenols, which, due to their antioxidant activity, show health benefits in humans. To reach a stage of pharmaceutical use, Arnica Montana flowers need to be processed into a viable product. For this purpose, various extractions techniques with different solvents were performed: cold maceration, ultrasounds, Soxhlet, and supercritical CO2; the solvents used were ethanol, methanol, and a 95:5 (v:v) mixture of ethanol and water. Analysis involving ultraviolet/visible spectrometry were accomplished to measure the antioxidant activity and the total phenolic content of the extracts. Finally, an organogel was formulated using the extract, cannabis oil, and rice bran wax and was tested for its stability. In the frame of this work, organogel with a high stability has been formulated for the first time, since until now, scientific literature does not provide any data of such kind of formulation. Additional studies will be required to determine its rheologic properties and solubility in different solvents at various temperature conditions.
Secondary keywords: Arnica Montana;organogels;solvent extraction;phenolic compounds;supercritical fluid extraction;
Type (COBISS): Master's thesis/paper
Thesis comment: Univ. v Mariboru, Fak. za kemijo in kemijsko tehnologijo
Pages: 1 spletni vir (1 datoteka PDF (44 f.))
ID: 15760609