Biotehnološki pristopi k zdravljenju kožnih bolezni

diplomsko delo

Ema Rezar (Author), Maša Vodovnik (Mentor)

Abstract

Kožne bolezni zasedajo četrto mesto na lestvici najbolj pogostih človeških obolenj. Do smrtnega izida vodi le manjši delež teh obolenj, zato je tudi manj pozornosti namenjeno njihovemu zdravljenju. Kljub vsemu pa kožne bolezni predstavljajo velikansko breme (fizično, psihološko, socialno-ekonomsko), ki vpliva tako na bolnika kot njegovo družino in navsezadnje tudi zdravstveni sistem. Trenutne oblike zdravljenja so pogosto opisane kot zastarele, neučinkovite in neprilagojene posamezniku, zato je potreba po razvoju novih velika. Področju biotehnoloških pristopov k zdravljenju kožnih obolenj se v zadnjih letih namenjata vse več pozornosti, kar se kaže v večjem številu raziskav in kliničnih študij. V povezavi z zdravljenjem kožnih bolezni se vse bolj poudarja tudi vlogo človeškega mikrobioma pri ohranjanju homeostaze, saj njegovo neravnovesje vodi do razvoja različnih, tudi kožnih bolezni. Določene oblike zdravljenja so zato ciljno usmerjene k ponovni vzpostaviti ravnovesja kožnega mikrobioma, kar vključuje manipulacijo mikrobioma s transplantacijo mikrobiote, probiotiki, prebiotiki, post-biotiki ali bakteriofagno terapijo. Za nekatere težje oziroma neozdravljive kožne bolezni po drugi strani razvijajo genske terapije, raziskave pa potekajo tudi na področju cepiv.

Keywords

biotehnologija;dermatologija;koža;kožne bolezni;mikrobiom;genska terapija;cepiva;

Data

Language:	Slovenian
Year of publishing:	2022
Typology:	2.11 - Undergraduate Thesis
Organization:	UL BF - Biotechnical Faculty
Publisher:	[E. Rezar]
UDC:	606:616.5(043.2)
COBISS:	114959363
Views:	75
Downloads:	38
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Biotechnological approaches for the treatment of skin diseases
Secondary abstract:	Skin diseases are fourth on the list of the most common human diseases. Only a couple of these diseases can be fatal, which is the reason they do not get as much attention as alternative research areas. Unfortunately, skin diseases represent an enormous burden (physical, psychological, socio-economic), affecting the patient, his family and, ultimately, the health care system. Current treatment strategies are generally considered outdated, ineffective and untailored to the individual, so the need for development of novel approaches in this area is emphasized. Lately, increasing interest is directed towards the novel approaches in treatment of skin diseases, which is reflected in the growing number of research and clinical studies. The role of the human microbiome in maintaining homeostasis is emphasized, as its imbalance leads to the development of various diseases, including many skin conditions. Therefore, an important approach in treatment of several skin conditions aims to restore the balance of skin as well as gut microbiome. This includes microbiome modulation by microbial transplantation, probiotics, prebiotics, post-biotics or the use of bacteriophage therapy. For some severe or incurable skin diseases, the field of gene therapy is also being explored. Furthermore, the development of vaccines targeting skin conditions is also discussed.
Secondary keywords:	biotechnology;dermatology;skin;skin diseases;microbiome;gene therapy;vaccines;
Type (COBISS):	Bachelor thesis/paper
Study programme:	0
Embargo end date (OpenAIRE):	1970-01-01
Thesis comment:	Univ. v Ljubljani, Biotehniška fak., Študij biotehnologije
Pages:	VI, 22 str.
ID:	15786462