Jurij-Matija Kališnik (Author), Klemen Steblovnik (Author), Eva Hrovat (Author), Aleš Jerin (Author), Milan Skitek (Author), Christian Dinges (Author), Theodor Fischlein (Author), Janez Žibert (Author)

Abstract

We have shown recently that minor subclinical creatinine dynamic changes enable excellent de-tection of acute kidney injury (AKI) within 6-12 hours after cardiac surgery. The aim of the pre-sent study was to examine combination of neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (CysC) and creatinine for enhanced AKI detection early after cardiac surgery. Elective patients with normal renal function undergoing cardiac surgery using cardiopulmonary bypass were enrolled. Concentrations of plasma NGAL, serum CysC and serum creatinine concentra-tions were determined after induction of general anaesthesia, at termination of cardiopulmo-nary bypass and 2 hours thereafter. Out of 119 enrolled patients 51 (43%) developed AKI. A model utilizing NGAL, CysC and creatinine triple biomarker panel including sequential rela-tive changes provides better prediction of cardiac surgery-associated acute kidney injury then any biomarker alone already 2 hours after the termination of cardiopulmonary bypass. The area under receiver-operator curve was 0.77, sensitivity 77% and specificity 68%.

Keywords

acute kidney injury;biomarker;cardiac surgery;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL ZF - University College of Health Studies
UDC: 616.12-089:616.61
COBISS: 107842819 Link will open in a new window
ISSN: 2308-3425
Views: 1300
Downloads: 249
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Other data

Secondary language: Slovenian
Secondary keywords: akutna poškodba ledvic;biomarkerji;srčna kirurgija;Biološki označevalci;Ledvice;
Type (COBISS): Article
Pages: str. 1-10
Volume: ǂVol. ǂ9
Issue: ǂno. ǂ7
Chronology: 2022
DOI: 10.3390/jcdd9070210
ID: 15795571