Protein release from nanocellulose and alginate hydrogels

ǂthe ǂstudy of adsorption and desorption kinetics

Tilen Kopač (Author), Matjaž Krajnc (Author), Aleš Ručigaj (Author)

Abstract

This work presents a study of the lysozyme release from crosslinked TEMPO nanocellulose (TOCNF) and alginate (ALG) hydrogels in a medium with different ionic strength and temperature. The main objective is to develop a mathematical model for a detailed study of the concurrent action of diffusion mechanism and adsorption/desorption kinetics. Model fit parameters provide important information about the initial (maximum) adsorption rate and its deceleration with increasing ionic strength of the release medium. Similarly, the initial (minimum) desorption rate and its acceleration with increasing salt concentration can be determined. The model leads us to the conclusion that the initial adsorption rate is higher in the case of TOCNF, but due to fewer electrostatic interactions and morphology as well as topography of the surface, it decreases to a negligible value much faster than in the case of ALG, where the diffusion process becomes dominant.

Keywords

linozim;adsorpcija;TEMPO nanoceluloza;alginat;kontrolirano sproščanje proteina;matematično modeliranje;lynozyme;adsorption;TEMPO nanocellulose;alginate;controlled protein release;mathematical modeling;

Data

Language:	English
Year of publishing:	2022
Typology:	1.01 - Original Scientific Article
Organization:	UL FKKT - Faculty of Chemistry and Chemical Technology
UDC:	678:544.4
COBISS:	113668355
ISSN:	0927-7765
Views:	89
Downloads:	49
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	Polimeri;
Type (COBISS):	Article
Pages:	str. 1-10
Issue:	ǂVol. ǂ217
Chronology:	1 Sep. 2022
DOI:	10.1016/j.colsurfb.2022.112677
ID:	15832357