Optimizacija sinteze tiadiazolov iz 4,4-dimetiltiosemikarbazida

diplomsko delo

Lana Kužnik (Author), Jakob Kljun (Mentor)

Abstract

V sklopu diplomskega dela sem načrtovala sintezo 1,3,4-tiadizolov z uporabo modelnih substratov. Sinteza je potekla z reakcijo med ketonom in 4,4-dimetiltiosemikarbazidom. Tiadiazoli, ki so produkti pri tej reakciji, so pomembni pri razvoju zdravilnih učinkovin zaradi svojih bioloških aktivnosti. V nadaljevanju sem optimizirala sintezni postopek spojin s spreminjanjem reakcijskih pogojev. Z uporabo metod za karakterizacijo (NMR, HRMS in CHN analizo) sem potrdila nastanek želenih produktov. Spojina pripravljena iz 4-(trifluorometil)acetofenona je kristalizirala in struktura je bila določena z rentgensko strukturno analizo. Čistost tiadiazolov in izkoristek reakcije bi lahko še izboljšala z nadaljnjo optimizacijo sinteznih postopkov.

Keywords

1,3,4-tiadiazoli;tiosemikarbazoni;4,4-dimetiltiosemikarbazid;Schiffove baze;razvoj zdravil;diplomske naloge;

Data

Language:	Slovenian
Year of publishing:	2022
Typology:	2.11 - Undergraduate Thesis
Organization:	UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher:	[L. Kužnik]
UDC:	547.78(043.2)
COBISS:	117129219
Views:	80
Downloads:	34
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Optimization of synthesis of thiadiazoles from 4,4-dimethylthiosemicarbazide
Secondary abstract:	As part of my thesis, I planned the synthesis of 1,3,4-thiadiazoles using model substrates. The synthesis was carried out by reaction between ketones and 4,4-dimethylthiosemicarbazide. Thiadiazoles, which are products of this reaction, are important in drug development because of their biological activities. I continued the optimization of synthetic processes of the compounds by changing the reaction conditions. Using the characterization methods (NMR, HRMS and CHN analysis), I confirmed the formation of the desired products. The compound prepared from 4- (trifluoromethyl)acetophenone crystallized and the structure was determined by X-ray structural analysis. The purity of thiadiazoles and the reaction yields could be improved by further optimization of synthetic procedures.
Secondary keywords:	1,3,4-thiadiazoles;4,4-dimethylthiosemicarbazide;drug development;Univerzitetna in visokošolska dela;
Type (COBISS):	Bachelor thesis/paper
Study programme:	1000374
Embargo end date (OpenAIRE):	1970-01-01
Thesis comment:	Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, VSŠ Kemijska tehnologija
Pages:	34 str.
ID:	15849316