diplomsko delo
Nastja Blagovič (Author), Polona Jamnik (Mentor)

Abstract

Tako oksidacijski kot redukcijski stres v celici lahko povzročata poškodbe, vendar je redukcijski stres veliko slabše raziskan. Redukcijski stres je posledica kopičenja reducentov ob hkratni nespremenjeni koncentraciji oksidantov. Po drugi strani redukcijski stres lahko tudi povzroči oksidacijski stres. Redoks reakcije so za normalno delovanje celice ključnega pomena, saj ustvarjajo energijo v obliki ATP. Prav zato je izredno pomembno, da je prisotno redoks ravnotežje, to je stanje, ko je prisotno ravnovesje med encimskimi in neencimskimi antioksidacijskimi sistemi ter produkcijo reaktivnih kisikovih zvrsti (ROS). Presežek reducentov v celici, kot so GSH, NADH ali čezmerno izražanje antioksidacijskih sistemov, lahko v celici izčrpa vse ROS in s tem povzroči redukcijski stres. Posledice redukcijskega stresa lahko opazujemo na celični ravni (zmanjšanje odziva celične rasti, zmanjšana funkcija mitohondrijev, znižanje aktivnosti metabolizma), hkrati pa je redukcijski stres lahko tudi vzrok za različna patološka stanja, kot so kardiovaskularne bolezni, rak, Alzheimerjeva bolezen itd.

Keywords

redukcijski stres;oksidacijski stres;celični metabolizem;ROS;antioksidanti;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UL BF - Biotechnical Faculty
Publisher: [N. Blagovič]
UDC: 606:61:601.4:577.2:576.36(043.2)
COBISS: 114940931 Link will open in a new window
Views: 43
Downloads: 18
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Other data

Secondary language: English
Secondary title: Cell reductive stress
Secondary abstract: Both oxidative and reductive stress cause cell damage, but reductive stress is much less researched. Reductive stress is caused by the accumulation of reducing agents while the concentration of oxidants remains unchanged. However, reductive stress can also induce oxidative stress. Redox reactions are crucial for normal cell function since they generate energy in the form of ATP. This is why the redox balance in the cell is extremely important. Redox balance is a state where the enzymatic and non-enzymatic antioxidant systems and the production of reactive oxygen species (ROS) are in balance. A surplus of reducing agents in the cell, such as GSH and NADH, or an over-regulation of the antioxidant systems can cause the depletion of ROS in the cell, leading to reductive stress. The consequences of reductive stress can be observed at the cellular level (reduced cell growth, reduced mitochondrial function, reduced metabolic activity). At the same time, reductive stress can also be the cause of various pathological conditions such as cardiovascular diseases, cancer, Alzheimer's disease, etc.
Secondary keywords: reductive stress;cell metabolism;oxidative stress;antioxidant;
Type (COBISS): Bachelor thesis/paper
Study programme: 0
Thesis comment: Univ. v Ljubljani, Biotehniška fak., Študij biotehnologije
Pages: VI, 19 str.
ID: 15891148