Sandra Ropret (Author), Jakob Jeriha (Author), Tjaša Sorčan (Author), Marija Rogar (Author), Špela Zemljič Jokhadar (Author), John A. McGrath (Author), Dusko Ilic (Author), Mirjana Liović (Author)

Abstract

We have generated MLi004-A, a new induced pluripotent stem cell (iPSC) line derived from skin fibroblasts of a female patient with recessive dystrophic epidermolysis bullosa (RDEB). This iPSC line may be used as a model system for studies on skin integrity, the extracellular matrix and skin barrier function. The characterization of the MLi004-A cell line consisted of molecular karyotyping, next-generation sequencing of the COL7A1 alleles, plu-ripotency and differentiation potentials testing by immunofluorescence of associated markers in vitro. The MLi- 004A line has been also tested for ability to differentiate into fibroblasts.

Keywords

matične celice;epidermoliza;kolagen VII;stem cell;epidermolysis;collagen VII;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL MF - Faculty of Medicine
UDC: 61
COBISS: 74980611 Link will open in a new window
ISSN: 1876-7753
Views: 52
Downloads: 29
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Other data

Secondary language: Slovenian
Secondary keywords: matične celice;epidermoliza;kolagen VII;
Type (COBISS): Article
Pages: str. 1-5
Issue: ǂVol. ǂ55
Chronology: Jul. 2021
DOI: 10.1016/j.scr.2021.102463
ID: 16261714