Current uncertainties and future challenges regarding NAD+ boosting strategies

Borut Poljšak (Author), Vito Kovač (Author), Irina Milisav (Author)

Abstract

Precursors of nicotinamide adenine dinucleotide (NAD+), modulators of enzymes of the NAD+ biosynthesis pathways and inhibitors of NAD+ consuming enzymes, are the main boosters of NAD+. Increasing public awareness and interest in anti-ageing strategies and health-promoting lifestyles have grown the interest in the use of NAD+ boosters as dietary supplements, both in scientific circles and among the general population. Here, we discuss the current trends in NAD+ precursor usage as well as the uncertainties in dosage, timing, safety, and side effects. There are many unknowns regarding pharmacokinetics and pharmacodynamics, particularly bioavailability, metabolism, and tissue specificity of NAD+ boosters. Given the lack of long-term safety studies, there is a need for more clinical trials to determine the proper dose of NAD+ boosters and treatment duration for aging prevention and as disease therapy. Further research will also need to address the long-term consequences of increased NAD+ and the best approaches and combinations to increase NAD+ levels. The answers to the above questions will contribute to the more efficient and safer use of NAD+ boosters.

Keywords

nikotinamid adenin dinukleotid;NAD+;NAD+ ojačevalci;prekurzorji NAD+;varnost;stranski učinki;nicotinamide adenine dinucleotide;NAD+ boosters;NAD+ precursors;safety;side effects;

Data

Language:	English
Year of publishing:	2022
Typology:	1.02 - Review Article
Organization:	UL MF - Faculty of Medicine
UDC:	613.98:616-092:66.094.3.097.8
COBISS:	119104771
ISSN:	2076-3921
Views:	26
Downloads:	12
Average score:	0 (0 votes)
Metadata:

Other data

Secondary keywords:	nikotinamid adenin dinukleotid;NAD+;NAD+ ojačevalci;prekurzorji NAD+;varnost;stranski učinki;
Type (COBISS):	Article
Pages:	str. 1-18
Volume:	ǂVol. ǂ11
Issue:	ǂiss. ǂ9
Chronology:	2022
DOI:	10.3390/antiox11091637
ID:	16270671