Halogenated ingredients of household and personal care products as emerging endocrine disruptors

Veronika Klančič (Author), Martina Gobec (Author), Žiga Jakopin (Author)

Abstract

The everyday use of household and personal care products (HPCPs) generates an enormous amount of chemicals, of which several groups warrant additional attention, including: (i) parabens, which are widely used as preservatives; (ii) bisphenols, which are used in the manufacture of plastics; (iii) UV filters, which are essential components of many cosmetic products; and (iv) alkylphenol ethoxylates, which are used extensively as non-ionic surfactants. These chemicals are released continuously into the environment, thus contaminating soil, water, plants and animals. Wastewater treatment and water disinfection procedures can convert these chemicals into halogenated transformation products, which end up in the environment and pose a potential threat to humans and wildlife. Indeed, while certain parent HPCP ingredients have been confirmed as endocrine disruptors, less is known about the endocrine activities of their halogenated derivatives. The aim of this review is first to examine the sources and occurrence of halogenated transformation products in the environment, and second to compare their endocrine-disrupting properties to those of their parent compounds (i.e., parabens, bisphenols, UV filters, alkylphenol ethoxylates). Albeit previous reports have focused individually on selected classes of such substances, none have considered the problem of their halogenated transformation products. This review therefore summarizes the available research on these halogenated compounds, highlights the potential exposure pathways, and underlines the existing knowledge gaps within their toxicological profiles.

Keywords

halogenated transformation products;parabens;bisphenols;UV filters;alkylphenol ethoxylates;endocrine disruption;

Data

Language:	English
Year of publishing:	2022
Typology:	1.02 - Review Article
Organization:	UL FFA - Faculty of Pharmacy
UDC:	612.43:620.266.1
COBISS:	117775107
ISSN:	0045-6535
Views:	32
Downloads:	21
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	halogenirani produkti transformacije;parabeni;bisfenoli;UV filtri;alkilfenol etoksilati;endokrine motnje;Hormonski motilci;
Type (COBISS):	Article
Pages:	19 str.
Volume:	ǂVol. ǂ303
Issue:	ǂpart ǂ1, art. 134824
Chronology:	2022
DOI:	10.1016/j.chemosphere.2022.134824
ID:	16317299