Sinteza amidov ketopinske kisline

diplomsko delo

Gašper Pavlin (Author), Uroš Grošelj (Mentor)

Abstract

Iz (1S)-(+)-10-kafrasulfonske kisline sem prek štirih reakcij uspešno pripravil želeni N-benzilamid ketopinske kisline. Za sintezo ketopinske kisline sem poskusil dva sintezna postopka. Prvi je dal s PCl5 slab izkoristek in nizko čistost nastale spojine, zato sem se odločil za drug postopek z uporabo SOCl2, ki je tudi dal boljše rezultate. N-benzilamid ketopinske kisline pa ni bil prvič pripravljen v okviru mojega eksperimentalnega dela, saj je spojina literaturno znana, bila pa je prvič v celoti okarakterizirana.

Keywords

organokataliza;kiralna pomagala;ketopinska kislina;kafrasulfonska kislina;amidi;diplomske naloge;

Data

Language:	Slovenian
Year of publishing:	2022
Typology:	2.11 - Undergraduate Thesis
Organization:	UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher:	[G. Pavlin]
UDC:	547-327(043.2)
COBISS:	124529923
Views:	48
Downloads:	15
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Synthesis of ketopinic acid amides
Secondary abstract:	I successfully prepared the desired N-benzylamide of ketopinic acid from (1S)-(+)-10-camphorsulfonic acid in four reaction steps. I tried two procedures for the synthesis of ketopinic acid. The first one with PCl5 gave poor yield and low purity of the resulting compound, so I decided on another procedure with SOCl2, which gave better results. N-benzylamide was not prepared for the first time as part of my experimental work, the compound is known from the literature, but it was fully characterized for the first time.
Secondary keywords:	organocatalysis;chiral auxiliaries;ketopinic acid;Organska sinteza (kemija);Univerzitetna in visokošolska dela;
Type (COBISS):	Bachelor thesis/paper
Study programme:	1000374
Embargo end date (OpenAIRE):	1970-01-01
Thesis comment:	Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, VSŠ Kemijska tehnologija
Pages:	28 str.
ID:	16336351