Sinteza oksazolonov, uporaba in biološka aktivnost

diplomsko delo

Jernej Pavlič (Author), Bogdan Štefane (Mentor)

Abstract

Oksazoloni so petčlenske heterociklične spojine, v katerih sta kot hetero atoma vključena kisik in dušik. Mesti C-2 in C-4 oksazolonov sta izrednega pomena, saj imata pomembno vlogo v bioloških in farmakoloških interakcijah. Z vezavo različnih substituentov na omenjeni mesti dobimo spojine s številnimi reakcijskimi mesti. N-substituirani oksazoloni prav tako sodelujejo v različnih intermolekularnih reakcijah. So ključni elementi pri sintezi raznolikih farmacevtskih učinkovin in biološko aktivnih spojin. Zaradi teh lastnosti je veliko interesa za to majhno heterociklično strukturo kot ciljno skupino spojin za oceno mnogih farmakoloških učinkov, kot so protimikrobni, pesticidni, inhibitorni, proti raku, proti diabetesu in protivnetni. V tej diplomski nalogi se bom osredotočil na mehanizem tvorbe oksazolona, različne oblike sinteze in farmakološke aktivnosti sintetiziranih spojin.

Keywords

oksazoloni;azlaktoni;sinteza Erlenmeyer-Plöchl;biološko aktivne spojine;pretvorbe oksazolonov;diplomske naloge;

Data

Language:	Slovenian
Year of publishing:	2022
Typology:	2.11 - Undergraduate Thesis
Organization:	UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher:	[J. Pavlič]
UDC:	547.78(043.2)
COBISS:	132900611
Views:	57
Downloads:	23
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Oxazolone synthesis, use and biological activity
Secondary abstract:	Oxazolones are five-membered heterocyclic compounds with oxygen and nitrogen included as hetero atoms. The C-2 and C-4 positions are vital as they play an important role in biological and pharmacological interactions. Compounds with many reaction sites are obtained by binding different substituents at the mentioned sites. N-substituted oxazolones also participate in various intermolecular reactions. They are vital elements in the synthesis of diverse pharmaceutical agents and biologically active compounds. Due to these properties, there is much interest in this small heterocyclic structure as a target group of compounds to evaluate many pharmacological effects such as antimicrobial, pesticidal, inhibitory, anticancer, antidiabetic and anti-inflammatory. In this thesis, I will focus on the mechanism of oxazolone formation, different forms of synthesis and pharmacological activities of the synthesized compounds.
Secondary keywords:	oxazolones;azlactones;Erlenmeyer-Plöchl synthesis;biologically active compounds;Univerzitetna in visokošolska dela;
Type (COBISS):	Bachelor thesis/paper
Study programme:	1000374
Embargo end date (OpenAIRE):	1970-01-01
Thesis comment:	Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, VSŠ Kemijska tehnologija
Pages:	33 str.
ID:	16706509