Anja Kolarič (Author), Marko Anderluh (Author), Nikola Minovski (Author)

Abstract

The emergence of bacterial resistance against life-saving medicines has forced the scientific community and pharmaceutical industry to take actions in the quest for novel antibacterials. These should not only overcome the existing bacterial resistance, but also provide at least interim effective protection against emerging bacterial infections. Research into DNA gyrase and topoisomerase IV inhibitors has become a particular focus, with the description of a new class of bacterial topoisomerase type II inhibitors known as "novel bacterial topoisomerase inhibitors" NBTIs. Elucidation of the key structural modifications incorporated into these inhibitors and the impact these can have on their general physicochemical properties are detailed in this review. This defines novel bacterial topoisomerase inhibitors with promising antibacterial activities and potencies, which thus represent one potential example of the future "drugs for bad bugs", as identified by the World Health Organization.

Keywords

zaviralci DNA giraze;topoizomeraza tip II;DNA gyrase inhibitors;antibacterials;novel bacterial topoisomerase inhibitors;intercalators;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL FFA - Faculty of Pharmacy
UDC: 615.015.8
COBISS: 4880241 Link will open in a new window
ISSN: 0022-2623
Views: 12
Downloads: 6
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Other data

Secondary language: Slovenian
Secondary keywords: Bakterijska rezistenca;
Type (COBISS): Article
Pages: str. 5664-5674
Volume: ǂVol. ǂ63
Issue: ǂiss. ǂ11
Chronology: 2020
DOI: 10.1021/acs.jmedchem.9b01738
ID: 16706512