ǂThe ǂeffect of design and size of the fluid-bed equipment on the particle size-dependent trend of particle coating thickness and drug prolonged-release profile

Teja Brezovar (Author), Grega Hudovornik (Author), Matjaž Perpar (Author), Matevž Luštrik (Author), Rok Dreu (Author)

Abstract

The focus of the current work is to study and demonstrate the impact of the design, the scale, and settings of fluid-bed coating equipment on the differences in pellet coating thickness, which in case of prolonged-release pellets dictates the drug release. In the first set of coating experiments, the pellet cores were coated with the Tartrazine dye with the aim of estimating the coating equipment performance in terms of coating thickness distribution, assessed through color hue. In the second set, drug-layered pellets were film-coated with prolonged-release coating and dissolution profile tests were performed to estimate the thickness and uniformity of the coating thickness among differently sized pellets. In both study parts, film coating was performed at the laboratory and the pilot scale and essentially two types of distribution plate and different height adjustments of the draft tube were compared. The dye coating study proved to be extremely useful, as the results enable process correction and the optimal use of the process equipment in combination with the appropriate process parameters. Preferential film coating of larger drug-containing pellets was confirmed on the laboratory scale, while on the pilot scale, it was possible to achieve preferential coating of smaller pellets using rational alternatives of settings, which is desirable in terms of particle size-independent drug release profile of such prolonged-release dosage forms.

Keywords

pellet film coating;Wurster chamber;swirl generator;prolonged release;preferential coating;

Data

Language:	English
Year of publishing:	2023
Typology:	1.01 - Original Scientific Article
Organization:	UL FFA - Faculty of Pharmacy
UDC:	615.45:661.12
COBISS:	147500291
ISSN:	1530-9932
Views:	28
Downloads:	10
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	peletna filmska prevleka;Wursterjeva komora;vrtinčni generator;podaljšano sproščanje;prednostna prevleka;Farmacevtska tehnologija;Farmacevtske oblike;
Type (COBISS):	Article
Pages:	16 str.
Volume:	ǂVol. ǂ24
Issue:	ǂiss. ǂ4, art. 93
Chronology:	2023
DOI:	10.1208/s12249-023-02540-9
ID:	18476512