Lidija Križančić Bombek (Author), Maša Čater (Author)

Abstract

Obesity and accompanying type 2 diabetes are among major and increasing worldwide problems that occur fundamentally due to excessive energy intake during its expenditure. Endotherms continuously consume a certain amount of energy to maintain core body temperature via thermogenic processes, mainly in brown adipose tissue and skeletal muscle. Skeletal muscle glucose utilization and heat production are significant and directly linked to body glucose homeostasis at rest, and especially during physical activity. However, this glucose balance is impaired in diabetic and obese states in humans and mice, and manifests as glucose resistance and altered muscle cell metabolism. Uncoupling proteins have a significant role in converting electrochemical energy into thermal energy without ATP generation. Different homologs of uncoupling proteins were identified, and their roles were linked to antioxidative activity and boosting glucose and lipid metabolism. From this perspective, uncoupling proteins were studied in correlation to the pathogenesis of diabetes and obesity and their possible treatments. Mice were extensively used as model organisms to study the physiology and pathophysiology of energy homeostasis. However, we should be aware of interstrain differences in mice models of obesity regarding thermogenesis and insulin resistance in skeletal muscles. Therefore, in this review, we gathered up-to-date knowledge on skeletal muscle uncoupling proteins and their effect on insulin sensitivity in mouse models of obesity and diabetes.

Keywords

fiziologija človeka;patofiziologija;diabetes;debelost;beljakovine;skeletne mišice;laboratorijske miši;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UM MF - Faculty of Medicine
UDC: 612
COBISS: 107486467 Link will open in a new window
ISSN: 2218-1989
Views: 41
Downloads: 4
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary language: Slovenian
Secondary keywords: fiziologija človeka;patofiziologija;diabetes;debelost;beljakovine;skeletne mišice;laboratorijske miši;
Type (COBISS): Scientific work
Pages: str. 1-22
Volume: ǂno. ǂ3
Issue: ǂart. ǂ259
Chronology: 2022
DOI: 10.3390/metabo12030259
ID: 19773934