Peripheral blood transcriptome in breast cancer patients as a source of less invasive immune biomarkers for personalized medicine, and implications for triple negative breast cancer

Helena Sabina Čelešnik (Author), Uroš Potočnik (Author)

Abstract

Transcriptome studies of peripheral blood cells can advance our understanding of the systemic immune response to the presence of cancer and the mechanisms underlying cancer onset and progression. This enables the identification of novel minimally invasive immune biomarkers for early cancer detection and personalized cancer management and may bring forward new immunotherapy options. Recent blood gene expression analyses in breast cancer (BC) identified distinct patient subtypes that differed in the immune reaction to cancer and were distinct from the clinical BC subtypes, which are categorized based on expression of specific receptors on tumor cells. Introducing new BC subtypes based on peripheral blood gene expression profiles may be appropriate, since it may assist in BC prognosis, the identification of patients likely to benefit from immunotherapy, and treatment efficacy monitoring. Triple-negative breast cancer (TNBC) is an aggressive, heterogeneous, and difficult-to-treat disease, and identification of novel biomarkers for this BC is crucial for clinical decision-making. A few studies have reported TNBC-enriched blood transcriptional signatures, mostly related to strong inflammation and augmentation of altered immune signaling, that can differentiate TNBC from other classical BC subtypes and facilitate diagnosis. Future research is geared toward transitioning from expression signatures in unfractionated blood cells to those in immune cell subpopulations.

Keywords

PBMC;peripheral blood;

Data

Language:	English
Year of publishing:	2022
Typology:	1.02 - Review Article
Organization:	UM - University of Maribor
UDC:	618.19-006
COBISS:	94899715
ISSN:	2072-6694
Views:	22
Downloads:	1
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	Triple negative breast neoplasms;Transcriptome;Gene expression;Biomarkers;
Type (COBISS):	Scientific work
Pages:	str. [1]-21
Volume:	ǂVol. ǂ14
Issue:	ǂissue ǂ3
Chronology:	2022
DOI:	10.3390/cancers14030591
ID:	19837835