Uporaba nanodelcev pri zdravljenju raka

diplomsko delo

Sara Zager (Author), Mojca Narat (Mentor)

Abstract

Konvencionalne terapije rakavih bolezni, kot so kemo-, radio-, imunoterapija, hormonska terapija in operativna odstranitev so sicer učinkovite, vendar jih zaradi sistemske aplikacije pogosto spremljajo akutni nezaželeni učinki in razvoj odpornosti na zdravila. Nanotehnologija je ena od možnosti, ki nam omogoča, da zmanjšamo pojavnost teh učinkov. Z njo dosežemo tarčno specifično ciljanje rakavih celic, medtem ko na okoliške zdrave celice uporabljeni terapevtski agensi ne učinkujejo. Z različnimi modifikacijami nanodelcev se lahko podaljša čas zadrževanja v tumorskem tkivu, lahko se poveča specifičnost do tumorskih celic, lahko pa se nanodelec modificira na način, da je z različnimi stimulusi sproženo nadzorovano sproščanje zdravilne učinkovine. Z nadaljnjim raziskovanjem tega področja se lahko doseže večja optimizacija nanodelcev, kar lahko v prihodnosti pomeni večjo učinkovitost zdravljenja raka in manjšo verjetnost za povrnitev le-tega.

Keywords

nanodelci;ciljana dostava;protirakave učinkovine;tumorsko mikrookolje;

Data

Language:	Slovenian
Year of publishing:	2023
Typology:	2.11 - Undergraduate Thesis
Organization:	UL BF - Biotechnical Faculty
Publisher:	[S. Zager]
UDC:	606:616-006.6:620.3(043.2)
COBISS:	162545923
Views:	34
Downloads:	12
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Use of nanoparticles for cancer treatment
Secondary abstract:	Conventional therapies for cancer diseases, such as chemotherapy, radiotherapy, immunotherapy, hormonal therapy, and surgical removal, are effective, but they often come with acute side effects and the development of drug resistance due to their systemic application. Nanotechnology is one of the options that allows us to reduce the occurrence of these effects. It enables specific targeting of cancer cells, while the therapeutic agents used do not affect the surrounding healthy cells. By using various modifications of nanoparticles, the retention time in tumor tissue can be prolonged, specificity to tumor cells can be increased, and the nanoparticles can be modified to achieve controlled release of the therapeutic agent triggered by different stimuli. Further research in this field can lead to greater optimization of nanoparticles, which may result in higher effectiveness of cancer treatment and a reduced likelihood of its recurrence in the future.
Secondary keywords:	nanoparticles;targeted delivery;antitumor drugs;tumor microenvironment;
Type (COBISS):	Bachelor thesis/paper
Study programme:	0
Embargo end date (OpenAIRE):	1970-01-01
Thesis comment:	Univ. v Ljubljani, Biotehniška fak., Študij biotehnologije
Pages:	1 spletni vir (1 datoteka PDF (VIII, 18 str.))
ID:	19853826