diplomsko delo
Ruta Koprivec (Author), Marjan Jereb (Mentor)

Abstract

Zaradi posebnih lastnosti fluorovega atoma se je v medicini, farmaciji in tudi drugih področjih močno povečalo zanimanje za fluorove spojine. V molekulo se lahko uvede kot samostojen fluorov atom ali kot fluorovo funkcionalno skupino. Zadnja leta so se znanstveniki med drugim osredotočili na trifluorometiltioliranje – reakcije, pri katerih se vodikov atom zamenja z močno elektrofilno in lipofilno SCF3 skupino. Za takšne reakcije so razvili različne nukleofilne in elektrofilne reagente, ki reagirajo z različnimi molekulami. Razvoj nukleofilnih reagentov se je najprej začel s kovinskimi reagenti, čez čas pa so jih nadomestili tudi manj škodljivi nekovinski reagenti, kot je na primer (Me4N)SCF3. Izmed elektrofilnih reagentov so najpogosteje v uporabi N-SCF3 reagenti kot je npr. N-trifluorometiltiosaharin. Odlično reagira z amini in tudi z mnogimi drugimi funkcionalnimi skupinami. V mnogih primerih so izkoristki visoki.

Keywords

fluorov atom;trifluorometiltioliranje;N-trifluorometiltiosaharin;elektrofilne reakcije;diplomska dela;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher: [R. Koprivec]
UDC: 547:546.16(043.2)
COBISS: 168358659 Link will open in a new window
Views: 69
Downloads: 13
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Other data

Secondary language: English
Secondary title: Trifluoromethylthiolation of amines
Secondary abstract: Due to the special properties of the fluorine atom interest in fluorine compounds has increased dramatically in medicine, pharmaceuticals and other fields. It can be incorporated into a molecule as a single fluorine atom or as a fluorine-containing functional group. In recent years, scientists have focused in particular on trifluoromethylthiolations – reactions in which the hydrogen atom is substituted by the strongly electrophilic and lipophilic SCF3 group. For such reactions, many nucleophilic and electrophilic reagents have been developed that react with different molecules. The development of nucleophilic reagents started with metal reagents, but over time they have been replaced by less harmful non-metallic reagents such as (Me4N)SCF3. The most commonly used electrophilic reagents are N-SCF3 reagents such as N-trifluoromethylthiosaccharin. It reacts excellently with amines and also with many other functional groups. In many cases, the yields are high.
Secondary keywords: fluorine atom;trifluoromethylthiolations;N-trifluoromethylthiosaccharin;amines;Amini;Fluorove spojine;Univerzitetna in visokošolska dela;
Type (COBISS): Bachelor thesis/paper
Study programme: 1000373
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, UNI Kemija
Pages: 32 str.
ID: 19896707