magistrsko delo
Blagoj Mukaetov (Author), Janez Košmrlj (Mentor), Matija Strlič (Thesis defence commission member), Marjan Jereb (Thesis defence commission member)

Abstract

Zgodnja in enostavna diagnostika Alzheimerjeve bolezni je še vedno eden od največjih izzivov pri tej bolezni, saj so trenutne metode za neposredno določanje bolezni drage in invazivne. V tej raziskovalni nalogi smo preučili šest novih molekul kot potencialne fluorescenčne sonde za detekcijo znanih biomarkerjev za Alzheimerjevo bolezen. Vse pripravljene spojine vsebujejo 2-fenilnaftalenski strukturni element z N,N dimetilaminom kot elektron donorsko skupino na eni in različnimi elektron-privlačnimi skupinami na drugi strani. Za tak tip spojin je značilno, da imajo paličasto strukturo, kar je ugodno tako za vezavo na biomarkerje kot tudi za »push-pull« učinek, ki omogoča, da molekule fluorescirajo. Zato smo poleg sinteze in karakterizacije omenjenim molekulam izmerili tudi absorpcijske, emisijske in ekscitacijske spektre ter določili molarne absorptivnosti in kvantne izkoristke. Sonde so pokazale dobre optične lastnosti, kot sta prisotnost batokromnega učinka in povečanje Stokesovega premika, ki sta pomembni lastnosti sond za potencialno uporabo pri diagnostiki Alzheimerjeve bolezni.

Keywords

Alzheimerjeva bolezen;fluorescenten sonde;2-fenilnaftalen;sintezne reakcije;reakcija po Sonogashiri;reakcija po Suzuki-Miyauri;Claisenova kondenzacija;Knoevenaglova kondenzacija;magistrska dela;

Data

Language: Slovenian
Year of publishing:
Typology: 2.09 - Master's Thesis
Organization: UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher: [B. Muaketov]
UDC: 547.65.057(043.2)
COBISS: 164009987 Link will open in a new window
Views: 7
Downloads: 2
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary language: English
Secondary title: Synthesis and optical properties of selected 2-phenylnaphthalene derivatives
Secondary abstract: The early and simple diagnosis of Alzheimer's disease remains one of the major challenges associated with the disease, as current methods for direct detection of the disease are expensive and inaccessible. In this work, six new molecules are presented as potential fluorescent probes for the detection of already known biomarkers for Alzheimer's disease. The molecules all contain a 2-phenylnaphthalene backbone with an electron-donating N,N dimethylamine group at one end and various electron-withdrawing groups at the other. These compounds are characterized by a rod-like structure that allows binding to biomarkers and promotes fluorescence by the "push-pull" method. In addition to the complete synthesis and characterization of the molecules, we measured the absorption, emission and excitation spectra and determined their molar absorption coefficients and quantum yields. The probes showed good optical properties, such as the presence of a bathochromic effect and an increase in the Stokes shift, implying that they could potentially be used for the diagnosis of Alzheimer’s disease.
Secondary keywords: Alzheimer's disease;fluorescent probes;2-phenylnaphthalene;Organska sinteza (kemija);Univerzitetna in visokošolska dela;
Type (COBISS): Master's thesis/paper
Study programme: 1000375
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, smer Kemija
Pages: XII f., 76 str.
ID: 19908959