diplomsko delo
Jure Grenc (Author), Jernej Ogorevc (Mentor)

Abstract

Cilj regenerativne medicine je obnoviti funkcijo poškodovanih organov in tkiv, to pa lahko dosežemo tudi s stimulacijo endogene regeneracije, ki predstavlja alternativo namnoževanju matičnih celic in njihovi presaditvi v poškodovano tkivo. Pri endogeni regeneraciji iz nepoškodovanih celic tkiva z uporabo različnih transkripcijskih dejavnikov induciramo mehanizme transdiferenciacije in dediferenciacije ter tako pridobimo celice sposobne proliferacije, s katerimi lahko nadomestimo propadle tipe celic. Omejitve pri uporabi teh pristopov predstavljata predvsem način vnosa in ne dovolj raziskano delovanje transkripcijskih dejavnikov, ki inducirajo mehanizem reprogramiranja celic, kljub temu pa se že razvijajo različne metode s potencialom za klinično rabo.

Keywords

biotehnologija;celično reprogramiranje;regeneracija tkiv;transformacija;dediferenciacija;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UL BF - Biotechnical Faculty
Publisher: [J. Grenc]
UDC: 606:616-003.93:601.4:577.21(043.2)
COBISS: 164710147 Link will open in a new window
Views: 31
Downloads: 12
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Other data

Secondary language: English
Secondary title: Direct cell reprogramming for tissue regeneration
Secondary abstract: The goal of regenerative medicine is to restore the function of damaged organs and tissues, which can also be achieved through the stimulation of endogenous regeneration. This represents an alternative to the proliferation of stem cells and their transplantation into the damaged tissue. In this process, we induce mechanisms of transdifferentiation and dedifferentiation from undamaged tissue cells using various transcription factors to obtain cells capable of proliferation or replacing lost cell types. The main limitation of these approaches lies in methods of transcription factors delivery and limited knowledge on functions of transcription factors, which induce cell reprogramming. Nevertheless, various methods with the potential for clinical use are already being developed.
Secondary keywords: biotechnology;cellular reprogramming;tissue regeneration;transformation;dedifferentiation;
Type (COBISS): Bachelor thesis/paper
Study programme: 0
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. v Ljubljani, Biotehniška fak., Študij biotehnologije
Pages: 1 spletni vir (1 datoteka PDF (VII, 16 str.))
ID: 19917071