diplomsko delo
Lucija Pintar (Author), Kristina Sepčić (Mentor)

Abstract

Liposomi so obetaven sistem za dostavo zdravilnih učinkovin, saj omogočajo enkapsulacijo tako hidrofobnih kot hidrofilnih učinkovin. Vendar je treba rešiti več izzivov, ki bi doprinesli k izboljšanju njihove učinkovitosti in možnosti širše uporabe v farmacevtiki. Pomembna področja raziskovanja obsegajo izboljšanje enkapsulacije, manipulacijo usode liposomov zaradi mononuklearnega fagocitnega sistema, reguliranje sproščanja zdravilnih učinkovin in izboljšanje prenosa tovora do ciljnih tkiv. Na zadrževanje zdravilne učinkovine v liposomu vplivajo topnost učinkovine v lipidnem dvosloju, interakcije z lipidi, velikost in sestava lipidov; enkapsulacijo bi torej lahko izboljšali, če bi prilagodili lipidno sestavo. Liposomi s hidrofilnimi polimernimi prevlekami krožijo dlje in se kopičijo v ciljnih tkivih, v celice pa vstopajo s fagocitozo in endocitozo, a se pogosto razgradijo v lizosomih. V nalogi so predstavljene raziskave in napredek na področju tehnologije liposomov, ki omogočajo premagovanje teh izzivov in razvoj izboljšanih liposomskih formulacij za različne medicinske namene.

Keywords

liposom;biokonjugacija;dostava zdravilnih učinkovin;nanomedicina;genska terapija;imunoterapija;PEGilacija;lipidni nanodelci;ciljna dostava;zdravila proti raku;farmakokinetika;ciljni ligand;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UL BF - Biotechnical Faculty
Publisher: [L. Pintar]
UDC: 602.628:577.115:606:615(043.2)
COBISS: 164780291 Link will open in a new window
Views: 17
Downloads: 7
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Other data

Secondary language: English
Secondary title: Liposomal drug delivery systems
Secondary abstract: Liposomes are a promising system for the delivery of drugs as they allow the encapsulation of both hydrophobic and hydrophilic drugs. Several challenges need to be addressed to improve liposmal efficiency and to allow for their wider use as pharmaceuticals. Important areas of research are directed towards improving the encapsulation, manipulation of the liposomal fate due to the mononuclear phagocytic system, regulating the release of drugs, and improving delivery to target tissues. Factors such as the drug solubility in the lipid bilayer, interactions with lipids, size and composition of lipids, influence the retention of the drug in the liposome, so the encapsulation could be improved by adjusting lipid composition. Liposomes with hydrophilic polymer coatings circulate longer, and accumulate in target tissues and enter cells by phagocytosis and endocytosis, but are often degraded in lysosomes. In this thesis, we present the latest research and advances in liposome technology that allow to overcome these challenges and develop improved liposome formulations for a variety of medical applications.
Secondary keywords: liposome;bioconjugation;drug delivery;nanomedicine;gene therapy;immunotherapy;PEGylation;lipid nanoparticles;targeted delivery;anticancer drugs;pharmacokinetics;targeting ligand;
Type (COBISS): Bachelor thesis/paper
Study programme: 0
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. v Ljubljani, Biotehniška fak., Študij biotehnologije
Pages: 1 spletni vir (1 datoteka PDF (VIII, 22 str.))
ID: 19929375