magistrsko delo
Urška Kovačič (Author), Marjan Marinšek (Mentor), Igor Plazl (Thesis defence commission member), Boštjan Genorio (Thesis defence commission member)

Abstract

Pokazalo se je, da je toksičnost vlaken povezana s potencialno biološko obstojnostjo vdihanih vlaken v pljučih. Toksikološki učinek je mogoče najbolje predvideti v tradicionalnih in dolgoročnih testih in vivo, vendar obstaja vse večje zanimanje za zamenjavo, zmanjšanje in izboljšanje alternativ testov na živalih. Potencialno topnost vlaken je mogoče opisati z in vitro acelularnimi testi, ki posnemajo pljučno okolje. Uporaba simuliranih pljučnih tekočin je obetavna in vitro metoda za boljše razumevanje mehanizmov sproščanja in predvidevanje in vivo obnašanja vlaken. V zadnjih letih so znanstveniki testirali različne simulirane pljučne tekočine, zato je v literaturi mogoče najti mnogo različnih verzij tekočin. Namen tega dela je ugotoviti, katera tekočina najbolje posnema realne biološke pogoje in zagotovi robustnost in ponovljivost, da bi se lahko čimprej odmaknili od testov na živalih.

Keywords

kamena mineralna vlakna;steklena mineralna vlakna;simulirana pljučna tekočina;statičen test;biološka obstojnost;magistrska dela;

Data

Language: Slovenian
Year of publishing:
Typology: 2.09 - Master's Thesis
Organization: UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher: [U. Kovačič]
UDC: 666.198:544.351.3(043.2)
COBISS: 173230083 Link will open in a new window
Views: 52
Downloads: 1
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Other data

Secondary language: English
Secondary title: In vitro acellular solubility of man-made mineral wool fibers in different simulated lung solutions
Secondary abstract: The toxicity of fiber has been shown to be related to the potential biodurability of respired fiber in the lung. The toxicological effect is best predicted in the traditional and long -term in vivo assays, but there is an increasing interest in replacement, reduction, and refinement of alternatives to animal testing. The potential solubility of fiber can be assessed by in vitro acellular test mimicking the lung environment. The use of simulated lung fluids is a promising in vitro method to better understand the release mechanisms and predicted in vivo fiber behaviour. In recent years, scientists have tested various simulated lung fluids, so many different versions of the fluids can be found in the literature. The aim of this work is to determine which fluid best mimics real biological conditions and provides robustness and reproducibility to move away from animal testing as soon as possible.
Secondary keywords: simulatede lung fluid;static test;biodurability;glass mineral wool;rock mineral wool;Kamena volna;Topnost;Univerzitetna in visokošolska dela;
Type (COBISS): Master's thesis/paper
Study programme: 1000376
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, smer Kemijsko inženirstvo
Pages: 123 str.
ID: 19999859