Vloga matičnih celic pri nastanku raka mlečne žleze

Rok Keber (Author)

Abstract

Rak mlečne žleze je najpogostejša oblika raka pri ženskah, zelo pogost pa je tudi pri nekaterih vrstah domačih živali (psi, mačke). Vse najnovejše raziskave s področja biologije mlečne žleze podpirajo hipotezo rakave matične celice, po kateri naj bi tumor izviral iz matične celice mlečne žleze ali njenih zgodnjih potomk. Tumorji nastanejo zaradi napake v uravnavanju sicer natančno kontroliranega procesa samoobnavljanja matičnih celic, kar je njihova temeljna lastnost. Tak tumor vsebuje subpopulacijo celic z lastnostmi matičnih celic, ki omogočajo razvoj in diferenciacijo tumorja ter prispevajo k celični heterogenosti. Vlogo rakavih matičnih celic v rakavem tkivu lahko primerjamo z vlogo normalnih matičnih celic v zdravem tkivu. Njihov obstoj je bil sprva dokazan pri krvnem raku, kasneje pa še pri malignih spremembah kompaktnih tkiv: možgan, prostate, debelega črevesa, trebušne slinavke in mlečne žleze. Identifikacija matičnih celic v zdravem in tumorskem tkivu mlečne žleze je razkrila vzroke za molekularno kompleksnost raka mlečne žleze pri ljudeh in živalih. Hipoteza rakave matične celice ima pomembno vlogo pri zgodnjem odkrivanju in zdravljenju dedne in sporadične oblike raka dojke pri ženskah. Matične celice z okvarjenim mehanizmom samoobnavljanja so odporne na obsevanje in kemoterapijo in zato predstavljajo osrednjo tarčo pri razvoju novih zdravil in strategij za zdravljenje raka dojke.

Keywords

mlečna žleza;matične celice;rak;medicina;

Data

Language:	Slovenian
Year of publishing:	2010
Typology:	1.02 - Review Article
Organization:	UL BF - Biotechnical Faculty
Publisher:	Biotehniška fakulteta
UDC:	616
COBISS:	2695048
ISSN:	1581-9175
Parent publication:	Acta agriculturae Slovenica
Views:	1365
Downloads:	316
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	ǂThe ǂrole of brest cancer stem cells in development of breast cancer
Secondary abstract:	Breast cancer is the most common type of cancer in women worldwide but also very common in domestic cats and dogs. Recent research in mammary gland biology has provided support for the cancer stem cell-hypothesis. The main focus of this hypothesis is that tumor originates from mammary stem or progenitor cells as a result of deregulation of the normally precise regulated process of self-renewal, which is their main characteristics. As a result, tumors contain and are driven by a cellular subcomponent that retains key stem-cell properties and enable development and differentiation of the tumor tissue, which results in extensive cellular heterogeneity. The role of cancer stem cells in cancer tissues resembles the role of normal stem cells in healthy tissue. Cancer stem cells have been first discovered in hematopoietic and later in solid cancers like brain, prostate, colon, pancreas and breast cancer. Identification of these cells in healthy and tumor breast tissue has helped to elucidate the origin of molecular complexity of breast cancer in humans and animals. The cancer stem-cell hypothesis has important implications for early detection and prevention of hereditary and sporadic form of breast cancer in humans. Aberrant stem cells with deregulated self-renewal mechanism are highly resistant to radiation and chemotherapy and therefore represent a central target in development of more effective drugs and therapies for breast cancer treatment.
Secondary keywords:	mammary gland;steam cells;cancer;medicine;
URN:	URN:NBN:SI
Type (COBISS):	Not categorized
Pages:	str. 43-51
Volume:	ǂLetn. ǂ96
Issue:	ǂšt. ǂ1
Chronology:	2010
Keywords (UDC):	applied sciences;medicine;technology;uporabne znanosti;medicina;tehnika;medical sciences;medicina;pathology;clinical medicine;patologija;klinična medicina;
ID:	21522