Biological applications of porous polymers and covalent organic frameworks

lecture at the Otto-von-Guericke Universität Magdeburg, Tuesday, 27th June 2023, Magdeburg, Germany

Abstract

Porous organic polymers (POPs) and covalent organic frameworks (COFs) have gained significant attention in the scientific community for a wide array of applications because of their attractive physical and chemical properties. Porosity of these materials provides ample surface area for interaction with targets, while crystallinity allows for highly specific structural tuning. In this seminar, I will present two strategies of utilizing these features of newly prepared materials in biosensing. Firstly, a cationic POP was synthesized, deposited onto interdigitated electrode arrays via a nontraditional electrophoresis technique, and utilized for electrochemical sensing of bacterial cells. As the principle of detection relied on electrostatic interactions between the cationic POP and the anionic bacterial surface, the sensor operated for both Gram-positive and Gram-negative bacteria. Secondly, a small-molecule nitroimidazole target for hypoxia, a low oxygen environment present in tumors, was post-synthetically conjugated to the pores of a fluorescent COF. This material served as a useful hypoxia imaging agent in cancerous cells. The seminar will conclude with some future perspectives on POPs and COFs in biological applications followed by Q & A.

Keywords

Porous organic polymers;covalent organic frameworks;biosensors;hypoxia;

Data

Language:	English
Year of publishing:	2023
Typology:	3.15 - Unpublished Conference Contribution
Organization:	UNG - University of Nova Gorica
UDC:	54
COBISS:	158691843
Views:	725
Downloads:	0
Average score:	0 (0 votes)
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Other data

Type (COBISS):	Not categorized
ID:	21815649