Tina Levstek (Author), Katarina Trebušak Podkrajšek (Author)

Abstract

Telomeres are dynamic DNA nucleoprotein structures located at the end of chromosomes where they maintain genomic stability. Due to the end replication problem, telomeres shorten with each cell division. Critically short telomeres trigger cellular senescence, which contributes to various degenerative and age-related diseases, including chronic kidney diseases (CKDs). Additionally, other factors such as oxidative stress may also contribute to accelerated telomere shortening. Indeed, telomeres are highly susceptible to oxidative damage due to their high guanine content. Here, we provide a comprehensive review of studies examining telomere length (TL) in CKDs to highlight the association between TL and the development and progression of CKDs in humans. We then focus on studies investigating TL in patients receiving kidney replacement therapy. The mechanisms of the relationship between TL and CKD are not fully understood, but a shorter TL has been associated with decreased kidney function and the progression of nephropathy. Interestingly, telomere lengthening has been observed in some patients in longitudinal studies. Hemodialysis has been shown to accelerate telomere erosion, whereas the uremic milieu is not reversed even in kidney transplantation patients. Overall, this review aims to provide insights into the biological significance of telomere attrition in the pathophysiology of kidney disease, which may contribute to the development of new strategies for the management of patients with CKDs.

Keywords

dolžina telomer;kronična ledvična bolezen;oksidativni stres;telomere length;chronic kidney disease;oxidative stress;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UL MF - Faculty of Medicine
UDC: 616.6
COBISS: 143131651 Link will open in a new window
ISSN: 2076-3921
Views: 41
Downloads: 7
Average score: 0 (0 votes)
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Other data

Secondary language: Slovenian
Secondary keywords: dolžina telomer;kronična ledvična bolezen;oksidativni stres;
Type (COBISS): Article
Pages: str. 1-14
Volume: ǂVol. ǂ12
Issue: ǂiss. ǂ3
Chronology: 2023
DOI: 10.3390/antiox12030579
ID: 22530099