Electrochemotherapy with cisplatin of breast cancer tumor modules in a male patient

Martina Reberšek (Author), Tanja Čufer (Author), Zvonimir Rudolf (Author), Gregor Serša (Author)

Abstract

Background. The metastases of breast cancer in a male patient were treated with electrochemotherapy by intratumoral injection of cisplatin. Electrochemotherapy is chemotherapy with the subsequent local application of electric pulses to the tumor nodules in order to increase drug delivery into the cells. Case report. Cutaneous metastases of breast cancer were treated with the intratumoral administration of cisplatin and by 8 electric pulses (1300 V/cm) applied a minute later to each cutaneous metastasis. The treatmentresulted in complete response of two electrochemotherapy treated cutaneous metastases and partial response of the third metastasis. In cutaneous metastases treated with intratumoral administartion of cisplatin without electric pulses, only partial response was obtained. Conclusion. This study confirms that electrochemotherapy with cisplatin is effective in the treatment of breast cancer metastases, too, as it was already proved for electrochemotherapy with bleomycin.

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Data

Language:	English
Year of publishing:	2000
Typology:	1.01 - Original Scientific Article
Organization:	OI - Institute of Oncology
Publisher:	Slovenian Medical Association - Slovenian Association of Radiology, Nuclear Medicine Society, Slovenian Society far Radiotherapy and Oncology, and Slovenian Cancer Society
UDC:	616-006
COBISS:	12586457
ISSN:	1318-2099
Views:	20
Downloads:	4
Average score:	0 (0 votes)
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Other data

Secondary language:	Slovenian
Secondary title:	Elektrokemoterapija s cisplatinom pri bolniku z rakom dojke
Secondary abstract:	Izvleček. Avtorji so zdravili kožne metastaze pri bolniku z rakom dojke z elektrokemoterapijo s cisplatinom. Elektrokemoterapija je zdravljenje s kemoterapijo, ki ji sledi lokalna aplikacija električnih pulzov na tumorske lezije; električni pulzi povečajo vnos kemoterapevtika v celice. Prikaz primera. Avtorji so zdravili kožne metastaze raka dojke z intratumorsko aplikacijo cisplatina in 8 električnimi pulzi, ki so jih na vsako kožno metastazo aplicirali 1 minuto po vnosu cisplatina. Pri zdravljenju z elektrokemoterapijo so pri dveh kožnih metastazah dosegli popolni odgovor, pri1 kožni metastazi pa delni odgovor. Pri kožnih metastazah, ki so jih zdravili samo z intratumorsko aplikacijo cispatina, pa so dosegli le delni odgovor. Zaključek. Elektrokemoterapija s cisplatinom je tako kot elektrokemoterapija z bleomicinom učinkovita pri zdravljenju kožnih metastaz raka na dojk.
Secondary keywords:	Breast neoplasms, male;Therapy;Drug therapy;Cisplatin;Drug delivery systems;Electroporation;
Source comment:	BSDOCID56903;
Pages:	str. 357-361
Volume:	ǂLetn. ǂ34
Issue:	ǂšt. ǂ4
Chronology:	2000
ID:	22609138