Postoperative radiochemotherapy for gastric adenocarcinoma

long term results

Irena Oblak (Author), Franc Anderluh (Author), Vaneja Velenik (Author)

Abstract

Background. To analyze the efficacy of postoperative radiochemotherapy with 5-florouracil (5-FU) and leucovorin (LV) applied in the patients with gastric carcinoma treated in a single institution. Patients and methods. Between 2001 and 2004, 123 patients with resected gastric adenocarcinoma were treated with postoperative concomitant radiochemotherapy with 5-FU and LV. The adjuvant treatment consisted of five cycles of chemotherapy with 5-FU (425mg/m2 IV) andLV (20 mg/m2 IV) and concomitant radiotherapy with the total dose of 45 Gy.Results. The treatment was completed according to the protocol in 82% of patients. The frequency and severity of early toxic effects induced by radiochemotherapy were manageable. Median follow-up time of 56 survivors was 64.5 months (range: 51.7-96.4 months). The 5-year locoregional control (LRC), diseasefree survival (DFS), disease-specific survival (DSS) and overall survival (OS) were 81%, 48.3%, 50.4%, and 48.4%, respectively. The multivariate analysis showed that the tumor involvement of cardia and low intensity of chemotherapy were independent adverse prognostic factors for DSS and OS. More advanced pT-stage and tumors with diffuse growth type according to Lauren were identified as negative independent prognostic factor for OS. They were also on the threshold of statistical significance for DSS. Conclusions. Postoperative radiochemotherapy for gastric carcinoma has acceptable toxicity, and is effective particularly in regard to LRC. High incidence of distant metastases calls for more effective systemic regimens.

Keywords

Adenocarcinoma;Adenokarcinom;Drug Therapy;Gastrectomy;Gastrektomija;Neoplasm Staging;Novotvorba, stadij;novotvorbe;Pathology;Preživetje, analiza;Radiotherapy;Stomach Neoplasms;Surgery;Survival Analysis;želodec;Želodec, novotvorbe

Data

Language:	English
Year of publishing:	2009
Typology:	1.01 - Original Scientific Article
Organization:	OI - Institute of Oncology
Publisher:	Association of Radiology and Oncology
UDC:	616-006
COBISS:	26682073
ISSN:	1318-2099
Parent publication:	Radiology and oncology
Views:	20
Downloads:	5
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary title:	Postoperativna radiokemoterapija pri bolnikih z rakom želodca
Secondary keywords:	Stomach Neoplasms;Surgery;Radiotherapy;Drug Therapy;Gastrectomy;Adenocarcinoma;Pathology;Neoplasm Staging;Survival Analysis;Preživetje, analiza;Adenokarcinom;Gastrektomija;Želodec, novotvorbe;Novotvorba, stadij;
Type (COBISS):	Not categorized
Source comment:	BSDOCID149803;
Pages:	str. 274-281
Volume:	ǂLetn. ǂ43
Issue:	ǂšt. ǂ4
Chronology:	2009
ID:	23111409