magistrsko delo
Zala Mesec (Author), Maša Knez Hrnčič (Mentor), Katja Andrina Kravanja (Co-mentor)

Abstract

V magistrskem delu smo želeli raziskati, ali lahko z enkapsulacijo zdravilne učinkovine (ketoprofena) v različne vrste nosilcev dosežemo njeno nadzorovano sproščanje v simuliranih telesnih tekočinah. Kot nosilce aktivnih učinkovin smo uporabili maltodekstrin, alginat, sojine proteine in polietilen glikol. Pridobljene enkapsulate smo najprej okarakterizirali z vrstičnim elektronskim mikroskopom in dobili mikrografe različnih povečav, ki so nam podali informacijo o morfoloških lastnostih produktov. Z metodo Fourierjeve transformacijske infrardeče spektroskopije smo preverili uspešnost vezave aktivne učinkovine v različne vrste nosilcev. Nato je sledilo še in vitro sproščanje zdravilne učinkovine iz polimernih nosilcev, ki je potekalo v simuliranih telesnih tekočinah. Ugotovili smo, katera formulacija je najprimernejša za doseganje nadzorovanega sproščanja v simuliranih telesnih tekočinah. Za vse pripravljene formulacije smo izrisali profile sproščanja in jim z matematičnimi modeli določili njihovo kinetiko sproščanja. Profili sproščanja posameznih formulacij so pokazali uspešno vezavo aktivne učinkovine v različne enkapsulate. V primerjavi s sproščanjem neformulirane aktivne učinkovine smo dosegli bolj nadzorovano sproščanje.

Keywords

ketoprofen;mikronizacija;enkapsulacija;in vitro sproščanje;matematični modeli;magistrske naloge;

Data

Language: Slovenian
Year of publishing:
Typology: 2.09 - Master's Thesis
Organization: UM FKKT - Faculty of Chemistry and Chemical Engineering
Publisher: [Z. Mesec]
UDC: 615.015.15(043.2)
COBISS: 195531011 Link will open in a new window
Views: 81
Downloads: 9
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Other data

Secondary language: English
Secondary title: Different formulation procedures and their impact on the release of pharmaceutical ingredients in simulated body fluids
Secondary abstract: In the master's thesis, we investigated whether it is possible to achieve controlled release in simulated body fluids by encapsulating the selected drug (ketoprofen) in different types of carriers, namely, maltodextrin, alginate, soy proteins, and polyethylene glycol. The encapsulates were first characterized using scanning electron microscopy to obtain microscopic images at different magnifications, showing the morphological properties of the products. Fourier transform infrared spectroscopy was used to demonstrate the successful incorporation of the drug into different types of polymeric carriers. This was followed by in vitro drug release tests carried out in simulated body fluids. The optimal formulation to achieve controlled release in simulated body fluids has been determined. In addition to obtaining the release profiles for all developed formulations, the release kinetic was evaluated using the selected mathematical models. Drug release profiles of individual formulations showed that the drug was successfully loaded into different polymeric carriers and that a more controlled release was achieved compared to the non-encapsulated drug.
Secondary keywords: ketoprofen;micronization;encapsulation;in vitro release;mathematical models;
Type (COBISS): Master's thesis/paper
Thesis comment: Univ. v Mariboru, Fak. za kemijo in kemijsko tehnologijo
Pages: 1 spletni vir (1 datoteka PDF (XI, 55 f.))
ID: 23114092