Mojca Jensterle Sever (Author), Sončka Jazbinšek (Author), Roman Bošnjak (Author), Mara Popović (Author), Lorna Zadravec-Zaletel (Author), Vesna Plesničar (Author), Barbara Faganel (Author), Primož Kotnik (Author)

Abstract

Childhood and adult-onset craniopharyngioma is a rare embryogenic tumor of the sellar, suprasellar, and parasellar region. Survival rates are high; however, tumor location and treatment sequalae including endocrine deficits, visual impairment, metabolic complications, cognitive and psychosocial deficits can significantly impair patient%s quality of life. There is considerable controversy regarding the optimal management of craniopharyngiomas. Subtotal resection of the tumor followed by targeted irradiation to avoid further hypothalamic damage is currently indicated. Novel insights in the tumor%s molecular pathology present the possibility for targeted therapy possibly decreasing the rate and severity of treatment-associated morbidity. Conclusions. Craniopharyngioma should be seen as a chronic disease. To achieve optimal outcomes a multidisciplinary team of specialized neurosurgeons, neuro-radiologists, neuro-oncologists, pathologists and endocrinologists should be involved in the diagnosis, planning of the surgery, irradiation and long-term follow-up.

Keywords

craniopharyngioma;hypopituitarism;metabolic syndrome;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: OI - Institute of Oncology
Publisher: Association of Radiology and Oncology
UDC: 616-006
COBISS: 34550489 Link will open in a new window
ISSN: 1318-2099
Views: 36
Downloads: 20
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Other data

Secondary language: Slovenian
Secondary keywords: kraniofaringiom;hipopituitarizem;presnovni sindrom;
Source comment: Soavtorji: Soncka Jazbinsek, Roman Bosnjak, Mara Popovic, Lorna Zadravec Zaletel, Tina Vipotnik Vesnaver, Barbara Faganel Kotnik, Primoz Kotnik;
Pages: str. 388-396, I
Volume: ǂVol. ǂ53
Issue: ǂno. ǂ4
Chronology: dec. 2019
DOI: 10.2478/raon-2019-0036
ID: 24493265