Bernarda Majc (Author), Tilen Sever (Author), Miki Zarić (Author), Barbara Breznik (Author), Boris Turk (Author), Tamara Lah Turnšek (Author)

Abstract

Epithelial-to-mesenchymal transition (EMT) is an essential molecular and cellular process that is part of normal embryogenesis and wound healing, and also has a ubiquitous role in various types of carcinoma and glioblastoma. EMT is activated and regulated by specific microenvironmental endogenous triggers and a complex network of signalling pathways. These mostly include epigenetic events that affect protein translation-controlling factors and proteases, altogether orchestrated by the switching on and off of oncogenes and tumour-suppressor genes in cancer cells. The hallmark of cancer-linked EMT is that the process is incomplete, as it is opposed by the reverse process of mesenchymal-to-epithelial transition, which results in a hybrid epithelial/mesenchymal phenotype that shows notable cell plasticity. This is a characteristic of cancer stem cells (CSCs), and it is of the utmost importance in their niche microenvironment, where it governs CSC migratory and invasive properties, thereby creating metastatic CSCs. These cells have high resistance to therapeutic treatments, in particular in glioblastoma.

Keywords

carcinomas;cancer stem cellsInvasion;proteases;tumour microenvironment;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: NIB - National Institute of Biology
UDC: 577
COBISS: 21291011 Link will open in a new window
ISSN: 0167-4889
Views: 19
Downloads: 9
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary language: Slovenian
Secondary keywords: rakave matične celice;invazija;proteaze;tumorsko mikrookolje;
Pages: str. 118782, 1-14
Volume: ǂVol. ǂ1867
Issue: ǂiss. ǂ10
Chronology: Oct. 2020
DOI: 10.1016/j.bbamcr.2020.118782
ID: 24670044