Anže Djordjević (Author), Stamenko Šušak (Author), Lazar Velicki (Author), Miha Antonič (Author)

Abstract

Cardiac surgery-associated acute kidney injury (CS-AKI) is a major complication associated with increased morbidity and mortality. There are multiple diagnostic criteria for CS-AKI. Despite many new investigations available for improved AKI diagnostics, creatinine and urea remain the cornerstone of diagnostics in everyday clinical practice. There are three major pathophysiological mechanisms that contribute to kidney injury, i.e. renal hypoperfusion, inflammation with oxidative stress, and use of nephrotoxic agents. Some risk factors have been identified that can be modified during the course of treatment (use of nephrotoxic agents, duration of cardiopulmonary bypass, type of extracorporeal circulation, postoperative low cardiac output or hypotension). The aim of AKI prevention should always be to prevent aggravation of renal failure and, if possible, to avoid progression to renal replacement therapy, which in turn brings worse long-term outcomes.

Keywords

kidney injuries;cardiac surgery;perfusion;oxidative stress;dialysis;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UM - University of Maribor
Publisher: Sestre milosrdnice University Hospital, Institute for Clinical Medical Research
UDC: 616.12-089
COBISS: 70352387 Link will open in a new window
ISSN: 1333-9451
Views: 27
Downloads: 1
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary language: Croatian
Secondary title: Akutno bubrežno oštećenje nakon operacija na otvorenom srcu
Secondary abstract: Akutno bubrežno oštećenje povezano s kardiokirurgijom (cardiac surgery-associated acute kidney injury, CS-AKI) je zna- čajna komplikacija s visokim pobolom i smrtnošću. Postoji više dijagnostičkih kriterija za dijagnozu CS-AKI. Usprkos mnogim novim istraživanjima, kreatinin i ureja ostaju temelj dijagnostike. Glavni patofiziološki procesi koji doprinose bubrežnom oštećenju su bubrežna hipoperfuzija, upala uzrokovana oksidativnim stresom i bubrežno oštećenje uzrokovano upotrebom nefrotoksičnih sredstava. Tijekom terapije može se utjecati na nekoliko čimbenika rizika (upotreba nefrotoksič- nih sredstava, trajanje kardiopulmonarne premosnice, tip izvantjelesne cirkulacije, smanjeni minutni volumen ili poslijeoperacijska hipotenzija). Cilj prevencije AKI je spriječiti progresiju bubrežnog oštećenja koje zahtijeva kompleksniju terapiju i donosi lošije dugoročne ishode.
Secondary keywords: Cardiac surgical procedures;Kardiokirurški postopki;Acute kidney injury;Akutna ledvična okvara;Perfusion;Perfuzija;Oxidative stress;Oksidativni stres;Dialysis;Dializa;
Type (COBISS): Scientific work
Source comment: Ključne besede v slovenščini: poškodbe ledvic, srčna kirurgija, perfuzija, oksidativni stres, dializa
Pages: str. 120-126
Volume: ǂVol. ǂ60
Issue: ǂno. ǂ1
Chronology: 2021
DOI: 10.20471/acc.2021.60.01.17
ID: 24689153