C–C bond formation reactions

Miha Drev (Author), Helena Brodnik Žugelj (Author), Uroš Grošelj (Author), Franc Perdih (Author), Jurij Svete (Author), Bogdan Štefane (Author), Franc Požgan (Author)

Abstract

A novel methodology for the synthesis of 2-pyridones bearing a 2-pyridyl group on nitrogen and carbon atoms, starting from 2-bromopyridines, was developed employing a simple Ru(II)–KOPiv–Na$_2$CO$_3$ catalytic system. Unsubstituted 2-bromopyridine was successfully converted to the penta-heteroarylated 2-pyridone product using this method. Preliminary mechanistic studies revealed a possible synthetic pathway leading to the multi-heteroarylated 2-pyridone products, involving consecutive oxygen incorporation, a Buchwald–Hartwig-type reaction, and C–H bond activation.

Keywords

rutenijeva kataliza;heterocikli;C-H aktivacija;piridoni;2-bromopiridini;ruthenium catalysis;heterocycles;C-H activation;pyridones;2-bromopyridines;

Data

Language:	English
Year of publishing:	2024
Typology:	1.01 - Original Scientific Article
Organization:	UL FKKT - Faculty of Chemistry and Chemical Technology
UDC:	547.82
COBISS:	208047363
ISSN:	1420-3049
Views:	30
Downloads:	17
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	rutenijeva kataliza;heterocikli;C-H aktivacija;piridoni;2-bromopiridini;
Type (COBISS):	Article
Pages:	str. 1-13
Volume:	ǂVol. ǂ29
Issue:	ǂiss. ǂ18, [article no.] 4418
Chronology:	Sep. 2024
DOI:	10.3390/molecules29184418
ID:	25105222