Niharika Rawat (Author), Ita Junkar (Author), Metka Benčina (Author), Tomaž Lampe (Author), Veronika Kralj-Iglič (Author), Aleš Iglič (Author)

Abstract

Biosensors are pivotal in biomedical applications, particularly for disease detection, diagnosis, treatment, health management, and monitoring. Titanium dioxide (TiO2) is a prominent material for biosensors due to its biocompatibility, corrosion resistance, and availability in various nanostructured forms. This study explores the interaction of platelets and extracellular vesicles (EVs) with different TiO2 surface morphologies using flow cytometry (FCM) and scanning electron microscopy (SEM). Blood plasma samples were incubated with various TiO2 surfaces to evaluate particle counts and characteristics. FCM results indicated a higher abundance of platelets compared to EVs, with significant fragmentation observed post-centrifugation. SEM analysis confirmed platelet activation and fragmentation, with the microflowered TiO2 surface displaying fewer vesicles due to its rough topography. The findings suggest that while TiO2 surface structuring minimally impacts particle counts, it influences platelet and EV interactions, highlighting the need for advanced detection techniques and further investigation into surface interactions.

Keywords

cold gaseous plasma;atmospheric pressure plasma;plasma technology;dental medicine;extracellular vesicles;surface treatment;

Data

Language: English
Year of publishing:
Typology: 1.08 - Published Scientific Conference Contribution
Organization: UL FE - Faculty of Electrical Engineering
UDC: 577:616.15
COBISS: 210339587 Link will open in a new window
Views: 47
Downloads: 3567
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Other data

Type (COBISS): Other
Pages: Str. 92-101
DOI: 10.55295/PSL.11.2024.11
ID: 25242013