towards innovative decision support systems
Eva Kočar (Author), Sonja Katz (Author), Žiga Pušnik (Author), Petra Bogovič (Author), Gabriele Turel (Author), Cene Skubic (Author), Tadeja Režen (Author), Franc Strle (Author), Vitor A. P. Martins dos Santos (Author), Miha Mraz (Author), Miha Moškon (Author), Damjana Rozman (Author)

Abstract

With COVID-19 becoming endemic, there is a continuing need to find biomarkers characterizing the disease and aiding in patient stratification. We studied the relation between COVID-19 and cholesterol biosynthesis by comparing 10 intermediates of cholesterol biosynthesis during the hospitalization of 164 patients (admission, disease deterioration, discharge) admitted to the University Medical Center of Ljubljana. The concentrations of zymosterol, 24-dehydrolathosterol, desmosterol, and zymostenol were significantly altered in COVID-19 patients. We further developed a predictive model for disease severity based on clinical parameters alone and their combination with a subset of sterols. Our machine learning models applying 8 clinical parameters predicted disease severity with excellent accuracy (AUC = 0.96), showing substantial improvement over current clinical risk scores. After including sterols, model performance remained better than COVID-GRAM. This is the first study to examine cholesterol biosynthesis during COVID-19 and shows that a subset of cholesterol-related sterols is associated with the severity of COVID-19.

Keywords

COVID-19;holesterol;biosinteza;steroli;lipidi;bioinformatika;ocenjevanje v zdravstveni tehnologiji;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL MF - Faculty of Medicine
UDC: 61:60:578
COBISS: 165467907 Link will open in a new window
ISSN: 2589-0042
Views: 48
Downloads: 4
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Other data

Secondary language: Slovenian
Secondary keywords: COVID-19;holesterol;biosinteza;steroli;lipidi;bioinformatika;ocenjevanje v zdravstveni tehnologiji;
Type (COBISS): Article
Pages: str. 1-16
Volume: ǂVol. ǂ26
Issue: ǂiss. ǂ10, [article no.] 107799
Chronology: 2023
DOI: 10.1016/j.isci.2023.107799
ID: 25429525