ǂa ǂsystematic review
Urška Rabuza (Author), Marko Pušnik (Author), Sergej Kmetec (Author), Darja Duh (Author), Sonja Šostar-Turk (Author)

Abstract

Disinfectants are used to reduce the concentration of pathogenic microorganisms to a safe level and help to prevent the transmission of infectious diseases. However, bacteria have a tremendous ability to respond to chemical stress caused by biocides, where overuse and improper use of disinfectants can be reflected in a reduced susceptibility of microorganisms. This review aims to describe whether mutations and thus decreased susceptibility to disinfectants occur in bacteria during disinfectant exposure. A systematic literature review following PRISMA guidelines was conducted with the databases PubMed, Science Direct and Web of Science. For the final analysis, 28 sources that remained of interest were included. Articles describing reduced susceptibility or the resistance of bacteria against seven different disinfectants were identified. The important deviation of the minimum inhibitory concentration was observed in multiple studies for disinfectants based on triclosan and chlorhexidine. A reduced susceptibility to disinfectants and potentially related problems with antibiotic resistance in clinically important bacterial strains are increasing. Since the use of disinfectants in the community is rising, it is clear that reasonable use of available and effective disinfectants is needed. It is necessary to develop and adopt strategies to control disinfectant resistance.

Keywords

antimicrobial resistance;susceptibility;disinfectants;bacteria;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UM FZV - Faculty of Health Sciences
Publisher: MDPI
UDC: 579.8:615.28:614.48
COBISS: 89566211 Link will open in a new window
ISSN: 2076-2607
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Downloads: 0
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Other data

Secondary language: Slovenian
Secondary keywords: Disinfection;Anti-bacterial agents;Microorganisms;Razkuževanje;Antibakterijska sredstva;Mikroorganizmi;
Type (COBISS): Scientific work
Pages: str. 1-22
Volume: ǂVol. ǂ9
Issue: ǂiss. ǂ12
Chronology: 10 Dec. 2021
DOI: 10.3390/microorganisms9122550
ID: 25480916