Razvoj eksperimentalnega procesnega sistema za preučevanje interakcij pri filmskem oblaganju tablet

magistrsko delo magistrskega študijskega programa II. stopnje Strojništvo

Andraž Bradač (Author), Gregor Bobovnik (Mentor), Iztok Golobič (Co-mentor)

Abstract

Proces filmskega oblaganja tablet je ključnega pomena za izboljšanje lastnosti tablete, kot so učinkovitost dostave učinkovin, odstranjevanje neprijetnega vonja ali okusa ter izboljšanje stabilnosti učinkovin. V nalogi smo obravnavali razvoj eksperimentalnega procesnega sistema za preučevanje interakcij pri filmskem oblaganju tablet. S pomočjo razvitega eksperimentalnega sistema, ki je vključeval dozirnik kapljic, temperaturno regulirano komoro in hitrotekočo kamero smo pri študiju interakcij med kapljico oblagalnega sredstva in površino tablete spremljali procese na mikroskopski ravni, vključno z vplivi temperature, velikosti in frekvence odlaganja kapljic ter obravnavali proces prenosa toplote in snovi pri nanašanju kapljic na površino tablete preko analize prodiranja vlage v in iz tablete. Obravnavan je vpliv volumna kapljice in oblagalnega sredstva na širino, globino in površino omočenosti tablete.

Keywords

magistrske naloge;tablete;filmske obloge;kapljica;eksperimentalni sistem;meritve;

Data

Language:	Slovenian
Year of publishing:	2024
Typology:	2.09 - Master's Thesis
Organization:	UL FS - Faculty of Mechanical Engineering
Publisher:	[A. Bradač]
UDC:	615.453.5:621.6.03(043.2)
COBISS:	221240835
Views:	67
Downloads:	35
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Development of an experimental process system to study interactions in film coating of tablets
Secondary abstract:	The tablet film coating process is essential to improve tablet properties such as the efficiency of delivery of active ingredients, the removal of unpleasant odour or taste, and the improvement of the stability of the active ingredients. In this thesis, the development of an experimental process system for the study of interactions in tablet film coating is addressed. Using the developed experimental system, which included a drop dispenser, a temperature-controlled chamber and a high-speed camera, we monitored the processes at the microscopic level, including the effects of temperature, droplet size and frequency of deposition, in the study of the interactions between the coating droplet and the tablet surface, and addressed the process of heat and material transfer in the deposition of droplets on the tablet surface through the analysis of the penetration of moisture into and out of the tablet. The impact of droplet volume and co-coating agent on the width, depth and wetting area of the tablet is analysed.
Secondary keywords:	master thesis;tablets;film coating;droplet;eksperimental sistem;measurements;
Type (COBISS):	Master's thesis/paper
Study programme:	0
Embargo end date (OpenAIRE):	1970-01-01
Thesis comment:	Univ. Ljubljana, Fak. za strojništvo
Pages:	XX, 64 str.
ID:	25546580