Hana Šinkovec (Author), Paul A. Kyrle (Author), Lisbeth Eischer (Author), Paul Gressenberger (Author), Thomas Gary (Author), Marianne Brodmann (Author), Georg Heinze (Author), Sabine Eichinger (Author)

Abstract

Background: The Vienna Prediction Model (VPM) identifies patients with a first unprovoked deep vein thrombosis of the leg and/or pulmonary embolism who have a low recurrence risk and may, therefore, not benefit from extended-phase anticoagulation. Objectives: The aim of this study was to evaluate patients with a predicted high risk of recurrent venous thromboembolism (VTE). Methods and Results: We prospectively followed 266 patients in whom the VPM had predicted a recurrence risk of more than 5.5% at 1 year for a median of 13.5 months. Their median age was 56 years, and 96% were men. After the VPM risk assessment, 196 patients restarted anticoagulation. While on anticoagulation, none of the patients experienced recurrent VTE, whereas 4 patients had nonmajor clinically relevant bleeding (absolute bleeding rate, 1.8 [95% CI, 0.5-4.5] events per 100 patient-years). Seventy patients were left untreated after VPM risk assessment for various reasons. Among patients not using anticoagulation, 15 had recurrence (absolute recurrence rate, 18.1 [95% CI, 10.1, 29.9] events per 100 person-years). According to the extended Kaplan–Meier analysis, the probability of VTE recurrence in patients not on anticoagulation was 10.1% and 17.9% at 6 and 12 months after VPM risk assessment, respectively. Conclusion: Anticoagulant therapy is effective and safe in patients with an unprovoked VTE, in whom the VPM had predicted a high risk of recurrent VTE. If these patients are left untreated, the risk of recurrence is high.

Keywords

deep vein thrombosis;pulmonary embolism;venous thromboembolism;Vienna Prediction Model recurrence;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL BF - Biotechnical Faculty
UDC: 616.1
COBISS: 221026307 Link will open in a new window
ISSN: 2475-0379
Views: 21
Downloads: 17
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Other data

Secondary language: Slovenian
Secondary keywords: globoka venska tromboza;pljučna embolija;venska trombembolija;
Type (COBISS): Article
Pages: 6 str.
Volume: ǂVol. ǂ9
Issue: ǂissue ǂ1, [article no.] 102649
Chronology: Jan. 2025
DOI: 10.1016/j.rpth.2024.102649
ID: 25639371