Optimization of the supercritical extraction and decarboxylation process of industrial hemp

Taja Žitek (Author), Petra Kotnik (Author), Teo Makoter (Author), Željko Knez (Author), Maša Knez Hrnčič (Author)

Abstract

Cannabinoids are the main active ingredients of Cannabis sativa L., obtained by a suitable extraction method and decarboxylation, in which the acid forms of the cannabinoids are converted into active forms. Supercritical CO2 extraction method and decarboxylation process were optimized for 7 cannabinoids (CBD, CBDA, THC, THCA, CBGA, CBN and CBC). The optimal extraction conditions for all cannabinoids were determined at a temperature of 60 °C and a pressure of 300 bar to 550 bar. At higher temperatures and reaction times, a significant depletion of neutral cannabinoids was observed. The optimal conditions of the decarboxylation process varied depending on the component. For the CBD component, which could be measured in the highest concentrations (560 mg/g), the optimal conditions were 140 °C and 10 min. The study can be an important model for predicting the behavior of cannabinoids under certain parameters.

Keywords

superkritične tekočine;kanabinoidi;dekarboksilacija;supercritical fluids;extraction;cannabinoids;decarboxilation;Cannabis sativa I;

Data

Language:	English
Year of publishing:	2025
Typology:	1.01 - Original Scientific Article
Organization:	UM FKKT - Faculty of Chemistry and Chemical Engineering
Publisher:	Elsevier Ltd.
UDC:	66.02
COBISS:	221113603
ISSN:	2212-9839
Views:	0
Downloads:	1
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	superkritične tekočine;kanabinoidi;dekarboksilacija;
Type (COBISS):	Article
Pages:	13 str.
Issue:	ǂVol. ǂ91, [article no.] 103007
Chronology:	Jan. 2025
DOI:	10.1016/j.jcou.2024.103007
ID:	25646406